Oxidative stress in Alzheimer's disease

V Chauhan, A Chauhan - Pathophysiology, 2006 - Elsevier
Oxidative damage is a major feature in the pathophysiology of Alzheimer's disease (AD). In
this review, we discuss free radical-mediated damage to the biochemical components …

Lipoic acid as a novel treatment for Alzheimer's disease and related dementias

L Holmquist, G Stuchbury, K Berbaum, S Muscat… - Pharmacology & …, 2007 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …

Antioxidant gene therapy against neuronal cell death

J Navarro-Yepes, L Zavala-Flores, A Anandhan… - Pharmacology & …, 2014 - Elsevier
Oxidative stress is a common hallmark of neuronal cell death associated with
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as …

Getting to NO Alzheimer's disease: neuroprotection versus neurotoxicity mediated by nitric oxide

R Balez, L Ooi - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder involving the loss of neurons in
the brain which leads to progressive memory loss and behavioral changes. To date, there …

Amyloid-β peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity

D Puzzo, O Vitolo, F Trinchese, JP Jacob… - Journal of …, 2005 - Soc Neuroscience
Amyloid-β (Aβ), a peptide thought to play a crucial role in Alzheimer's disease (AD), has
many targets that, in turn, activate different second-messenger cascades. Interestingly, Aβ …

[HTML][HTML] Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves

AR Ciampa, AC de Prati, E Amelio, E Cavalieri… - FEBS letters, 2005 - Elsevier
Here, we show that extracorporeal shock waves (ESW), at a low energy density value,
quickly increase neuronal nitric oxide synthase (nNOS) activity and basal nitric oxide (NO) …

[HTML][HTML] Synaptic therapy in Alzheimer's disease: a CREB-centric approach

AF Teich, RE Nicholls, D Puzzo, J Fiorito, R Purgatorio… - …, 2015 - Elsevier
Therapeutic attempts to cure Alzheimer's disease (AD) have failed, and new strategies are
desperately needed. Motivated by this reality, many laboratories (including our own) have …

Neuromodulatory action of picomolar extracellular Aβ42 oligomers on presynaptic and postsynaptic mechanisms underlying synaptic function and memory

W Gulisano, M Melone, C Ripoli… - Journal of …, 2019 - Soc Neuroscience
Failure of anti-amyloid-β peptide (Aβ) therapies against Alzheimer's disease (AD), a
neurodegenerative disorder characterized by high amounts of the peptide in the brain …

Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and α-lipoic acid against HNE …

HM Abdul, DA Butterfield - Free Radical Biology and Medicine, 2007 - Elsevier
Oxidative stress has been shown to underlie neuropathological aspects of Alzheimer's
disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of lipid peroxidation …

[HTML][HTML] L-Norvaline reverses cognitive decline and synaptic loss in a murine model of Alzheimer's disease

B Polis, KD Srikanth, E Elliott, H Gil-Henn, AO Samson - Neurotherapeutics, 2018 - Elsevier
The urea cycle is strongly implicated in the pathogenesis of Alzheimer's disease (AD).
Arginase-I (ARGI) accumulation at sites of amyloid-beta (Aβ) deposition is associated with L …