GM-CSF, IL-3, and IL-5 family of cytokines: regulators of inflammation
M Dougan, G Dranoff, SK Dougan - Immunity, 2019 - cell.com
The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory
responses that promote the rapid clearance of pathogens but also contribute to pathology in …
responses that promote the rapid clearance of pathogens but also contribute to pathology in …
CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies
U Testa, E Pelosi, A Frankel - Biomarker research, 2014 - Springer
Recent studies indicate that abnormalities of the alpha-chain of the interleukin-3 receptor (IL-
3RA or CD123) are frequently observed in some leukemic disorders and may contribute to …
3RA or CD123) are frequently observed in some leukemic disorders and may contribute to …
The GM–CSF/IL‐3/IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling
SE Broughton, U Dhagat, TR Hercus… - Immunological …, 2012 - Wiley Online Library
Granulocyte–macrophage colony‐stimulating factor (GM–CSF), interleukin‐3 (IL‐3), and IL‐
5 are members of a discrete family of cytokines that regulates the growth, differentiation …
5 are members of a discrete family of cytokines that regulates the growth, differentiation …
Hematopoietic cytokine receptor signaling
Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are
mediated by cytokines and their receptors. Proper culmination of these diverse pathways …
mediated by cytokines and their receptors. Proper culmination of these diverse pathways …
Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation
Stat5a and Stat5b are discretely encoded transcription factors that mediate signals for a
broad spectrum of cytokines. Their activation is often an integral component of redundant …
broad spectrum of cytokines. Their activation is often an integral component of redundant …
IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled
Hematopoiesis is the cumulative result of intricately regulated signal transduction cascades
that are mediated by cytokines and their cognate receptors. Proper culmination of these …
that are mediated by cytokines and their cognate receptors. Proper culmination of these …
Antibody therapies for acute myeloid leukemia: unconjugated, toxin-conjugated, radio-conjugated and multivalent formats
BA Williams, A Law, J Hunyadkurti, S Desilets… - Journal of clinical …, 2019 - mdpi.com
In recent decades, therapy for acute myeloid leukemia (AML) has remained relatively
unchanged, with chemotherapy regimens primarily consisting of an induction regimen …
unchanged, with chemotherapy regimens primarily consisting of an induction regimen …
The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes
I Del Giudice, E Matutes, R Morilla, A Morilla… - …, 2004 - haematologica.org
BACKGROUND AND OBJECTIVES: CD123 is an antibody that identifies the a chain of the
human interleukin-3 receptor and is expressed in a variety of normal hematopoietic cells …
human interleukin-3 receptor and is expressed in a variety of normal hematopoietic cells …
IL-3 in the development and function of basophils
The β common chain (βc) cytokine family includes granulocyte-macrophage colony-
stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5, all of which use βc as key …
stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5, all of which use βc as key …