Diabetes mellitus is a high prevalence and one of the most severe and lethal diseases in the
world. Insulin is commonly used to treat diabetes in order to give patients a better life …

Recent developments in materials science and specific surface functionalization of materials
are providing new tools for the rational design of precisely engineered drug delivery …

Introduction: The popularity of nanotechnology is increasing and revolutionizing extensively
the drug delivery field. Nanoparticles, as carriers for oral delivery of drugs, have been …

Oral administration remains the preferred dosing method in clinical practice and drug
development. Oral bioavailability (F) is a function of the fraction absorbed (Fabs) …

Context: Gambogic acid (GA) can inhibit the growth of various cancer cells. However, the
low bioavailability caused by insolubility, limits its clinical application. L-arginine is always …

Objective The aim of this study was to explore the efficacy of insulin-loaded trimethylchitosan
nanoparticles on certain destructive effects of diabetes type one. Materials and methods …

Background: Subcutaneous injection of insulin can lead to problems such as hypoglycemia
and edema. Objective: The purpose of this research was to evaluate the effect of oral insulin …

Polysaccharides are complex carbohydrate molecules typically composed of mono-or
disaccharide units linked by glycosidic bonds, which allows their structural organization into …

BACKGROUND: Type 2 diabetes (T2D) has been reproducibly clustered into five subtypes
based on six-clinical variables; age at diabetes onset, body mass index (BMI), Glutamic acid …

This PhD Thesis entitled “Optimization of Lyophilization Parameters of Polymeric
Nanoparticles for Delivery of Therapeutic Proteins” has been submitted to meet the …