Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Osteoarthritis (OA) is the most common joint disease worldwide and a leading cause of
disability. Characterized by degradation of articular cartilage, synovial inflammation, and …

Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor
types, including colon cancer. Aberrant activation of this pathway is associated with cell …

How basal cell carcinoma (BCC) interacts with its tumor microenvironment to promote
growth is unclear. We use singe-cell RNA sequencing to define the human BCC ecosystem …

Wnt5a is the prototypical activator of the non-canonical Wnt pathways, and its
overexpression has been implicated in the progression of several tumor types by promoting …

The global burden of obesity has multiplied owing to its rapidly growing prevalence and
obesity-related morbidity and mortality. In addition to the classic role of depositing extra …

Type 2 diabetes mellitus (T2DM) is one of the major chronic diseases, whose prevalence is
increasing dramatically worldwide and can lead to a range of serious complications. Wnt …

Abstract Decabrominated diphenyl ether (BDE-209), a persistent organic pollutant, is linked
to a great number of health problems, the most severe of which impact the liver due to its …

Development of an effective treatment against advanced tumors remains a major challenge
for cancer immunotherapy. Approximately 50% of human melanoma is driven by B-Raf proto …