Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium.
Their functions are strikingly multifaceted, ranging from hemoglobin degradation to secretory …

Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to
barrier penetration, tissue dissemination, inflammation, and pathogen transmission. Like cell …

Malaria is a devastating parasitic disease affecting half of the world's population. The rapid
emergence of resistance against new antimalarial drugs, including artemisinin‐based …

All intracellular pathogens must escape (egress) from the confines of their host cell to
disseminate and proliferate. The malaria parasite only replicates in an intracellular vacuole …

Plasmepsins represent novel antimalarial drug targets. However, plasmepsin-based
antimalarial drug discovery efforts in the past 2 decades have generally suffered some …

The circumsporozoite protein (CSP) is one of the most studied proteins of the malaria
parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite …

Plasmodium sporozoites are the infective forms of the malaria parasite in the mosquito and
vertebrate host. Gliding motility allows sporozoites to migrate and invade mosquito salivary …

The family of apicomplexan specific proteins contains caspases–like proteins called
“metacaspases”. These enzymes are present in the malaria parasite but absent in human; …

Malaria parasite transmission to humans is initiated by the inoculation of Plasmodium
sporozoites into the skin by mosquitoes. Sporozoites develop within mosquito midgut …