Leishmaniasis is a neglected infectious disease caused by several different species of
protozoan parasites of the genus Leishmania. Current strategies to control this disease are …

Parasitic protozoa of the genus Leishmania have provided a useful perspective for
immunologists in terms of host defense mechanisms critical for the resolution of infection …

Cutaneous leishmaniasis affects millions of people around the world. Several species of
Leishmania infect mouse strains, and murine models closely reproduce the cutaneous …

The requirements for effective and efficient intracellular killing of Leishmania amazonensis
by activated macrophages are unknown. Despite resistance to the arginase inhibitor LOHA …

Abstract Type I IFNs (IFN-α/β) have only recently gained considerable attention as
immunomodulators in nonviral infectious diseases. IFN-β has been shown to protect, in a …

Background Reactive oxygen species (ROS) protect the host against a large number of
pathogenic microorganisms. ROS have different effects on parasites of the genus …

Leukotrienes (LTs) are known to be produced by macrophages when challenged with
Leishmania, but it is not known whether these lipid mediators play a role in host defense …

The murine models of Leishmania infection are well-studied and suitable models for
studying this disease, which, despite its incidence of nearly 2 million new cases worldwide …

Leishmania is a protozoan parasite that causes a wide range of different clinical
manifestations in mammalian hosts. It is a major public health risk on different continents …

Neutrophils are involved in the early stages of immune responses to pathogens. Here, we
investigated the role of neutrophils during the establishment of L eishmania amazonensis …