Ultrasound-targeted microbubble destruction remodels tumour microenvironment to improve immunotherapeutic effect

S Liu, Y Zhang, Y Liu, W Wang, S Gao, W Yuan… - British Journal of …, 2023 - nature.com
Cancer immunotherapy (CIT) has gained increasing attention and made promising progress
in recent years, especially immune checkpoint inhibitors such as antibodies blocking …

Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches

LJ Delaney, S Isguven, JR Eisenbrey, NJ Hickok… - Materials …, 2022 - pubs.rsc.org
Administration of drugs through oral and intravenous routes is a mainstay of modern
medicine, but this approach suffers from limitations associated with off-target side effects and …

Ultrasound and nanomaterial: an efficient pair to fight cancer

E Alphandéry - Journal of Nanobiotechnology, 2022 - Springer
Ultrasounds are often used in cancer treatment protocols, eg to collect tumor tissues in the
right location using ultrasound-guided biopsy, to image the region of the tumor using more …

[HTML][HTML] From concept to early clinical trials: 30 years of microbubble-based ultrasound-mediated drug delivery research

A Bouakaz, JM Escoffre - Advanced Drug Delivery Reviews, 2024 - Elsevier
Ultrasound mediated drug delivery, a promising therapeutic modality, has evolved
remarkably over the past three decades. Initially designed to enhance contrast in ultrasound …

Landscape of cellular bioeffects triggered by ultrasound-induced sonoporation

D Przystupski, M Ussowicz - International journal of molecular sciences, 2022 - mdpi.com
Sonoporation is the process of transient pore formation in the cell membrane triggered by
ultrasound (US). Numerous studies have provided us with firm evidence that sonoporation …

Delivering the CRISPR/Cas9 system for engineering gene therapies: Recent cargo and delivery approaches for clinical translation

RA Foley, RA Sims, EC Duggan, JK Olmedo… - … in Bioengineering and …, 2022 - frontiersin.org
Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9
(CRISPR/Cas9) has transformed our ability to edit the human genome selectively. This …

[HTML][HTML] Focused ultrasound hyperthermia augments release of glioma-derived extracellular vesicles with differential immunomodulatory capacity

ND Sheybani, AJ Batts, AS Mathew, EA Thim… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Increasing evidence points to the critical role of extracellular vesicles (EVs) as
molecular parcels that carry a diverse array of bioactive payloads for coordination of …

Immunotheranostic microbubbles (iMBs)-a modular platform for dendritic cell vaccine delivery applied to breast cancer immunotherapy

N Jugniot, JJ Dahl, R Paulmurugan - Journal of Experimental & Clinical …, 2022 - Springer
Background Therapeutic strategies engaging the immune system against malignant cells
have revolutionized the field of oncology. Proficiency of dendritic cells (DCs) for antigen …

Delivery of anti-cancer drugs using microbubble-assisted ultrasound in digestive oncology: from preclinical to clinical studies

JM Escoffre, N Sekkat, E Oujagir, S Bodard… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The combination of microbubbles (MBs) and ultrasound (US) is an emerging
method for the noninvasive and targeted enhancement of intratumor chemotherapeutic …

[HTML][HTML] Calcium ion delivery by microbubble-assisted sonoporation stimulates cell death in human gastrointestinal cancer cells

D Przystupski, D Baczyńska, J Rossowska… - Biomedicine & …, 2024 - Elsevier
Ultrasound-mediated cell membrane permeabilization–sonoporation, enhances drug
delivery directly to tumor sites while reducing systemic side effects. The potential of …