Recent work on the MACPF/CDC superfamily of pore-forming proteins has focused on the
structural analysis of monomers and pore-forming oligomeric complexes. We set the family …

Cytotoxic T lymphocytes and natural killer cells eliminate infected cells from the organism by
triggering programmed cell death (apoptosis). The contents of the lytic granules of killer …

Physiological aging is accompanied by a marked reduction in natural killer (NK) cell
cytotoxicity (NKCC) at the single cell level, but the underlying mechanisms are unknown. To …

Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/-
mouse studies having informed our understanding of GZMA's physiological function. We …

Purpose Granzyme A (GZMA) is a potential prognostic target for various cancer types.
However, its therapeutic significance in breast cancer with immune infiltration remains …

A cell-in-cell process refers to the invasion of one living cell into another homotypic or
heterotypic cell. Different from non-apoptotic death processes of internalized cells termed …

Granzyme A (GzmA) is secreted by cytotoxic lymphocytes and has traditionally been viewed
as a mediator of cell death. However, a growing body of data suggests the physiological role …

Abstract Methylmercury (MeHg), cadmium (Cd) and arsenic (As (III)) are among the most
toxic metals in aquatic systems that have been associated with multiple animal and human …

Cytotoxic lymphocytes eliminate virally infected or neoplastic cells through the action of
cytotoxic proteases (granzymes). The pore-forming protein perforin is essential for delivery …

The effects of local factors on activation of immune cells infiltrating the central nervous
system (CNS) in a rat model of traumatic brain injury (TBI) remain elusive. The cytokine …