[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
Mechanisms regulating skeletal muscle growth and atrophy
Skeletal muscle mass increases during postnatal development through a process of
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …
on individuals and society. The development of preventive and therapeutic strategies …
Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate
establishment and maintenance of these sizes remain poorly understood. This is especially …
establishment and maintenance of these sizes remain poorly understood. This is especially …
Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation
Recent loss-of-function studies show that satellite cell depletion does not promote
sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although …
sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although …
Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice
Background Pax7+ satellite cells are required for skeletal muscle fiber growth during post-
natal development in mice. Satellite cell-mediated myonuclear accretion also appears to …
natal development in mice. Satellite cell-mediated myonuclear accretion also appears to …
The myonuclear domain in adult skeletal muscle fibres: past, present and future
Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely
multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which …
multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which …
Myonuclear domain flexibility challenges rigid assumptions on satellite cell contribution to skeletal muscle fiber hypertrophy
KA Murach, DA Englund… - Frontiers in …, 2018 - frontiersin.org
Satellite cell-mediated myonuclear accretion is thought to be required for skeletal muscle
fiber hypertrophy, and even drive hypertrophy by preceding growth. Recent studies in …
fiber hypertrophy, and even drive hypertrophy by preceding growth. Recent studies in …
Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men
N Gharahdaghi, S Rudrappa, MS Brook… - Journal of Cachexia …, 2019 - Wiley Online Library
Background The andropause is associated with declines in serum testosterone (T), loss of
muscle mass (sarcopenia), and frailty. Two major interventions purported to offset …
muscle mass (sarcopenia), and frailty. Two major interventions purported to offset …
Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations
Multinucleated skeletal muscle cells need to acquire additional nuclei through fusion with
activated skeletal muscle stem cells when responding to both developmental and adaptive …
activated skeletal muscle stem cells when responding to both developmental and adaptive …