An update on the biology of sphingosine 1-phosphate receptors
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …
Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
Modulation of sphingosine-1-phosphate in inflammatory bowel disease
L Peyrin-Biroulet, R Christopher, D Behan… - Autoimmunity reviews, 2017 - Elsevier
Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, involve
an inappropriate immune reaction in the digestive tract, causing a variety of disabling …
an inappropriate immune reaction in the digestive tract, causing a variety of disabling …
Finding a way out: S1P signaling and immune cell migration
AAL Baeyens, SR Schwab - Annual review of immunology, 2020 - annualreviews.org
The signaling lipid sphingosine 1-phosphate (S1P) plays critical roles in an immune
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …
Sphingosine 1-phosphate receptors and metabolic enzymes as druggable targets for brain diseases
S Grassi, L Mauri, S Prioni, L Cabitta… - Frontiers in …, 2019 - frontiersin.org
The central nervous system is characterized by a high content of sphingolipids and by a high
diversity in terms of different structures. Stage-and cell-specific sphingolipid metabolism and …
diversity in terms of different structures. Stage-and cell-specific sphingolipid metabolism and …
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1
K Janes, JW Little, C Li, L Bryant, C Chen… - Journal of Biological …, 2014 - ASBMB
The ceramide-sphingosine 1-phosphate (S1P) rheostat is important in regulating cell fate.
Several chemotherapeutic agents, including paclitaxel (Taxol), involve pro-apoptotic …
Several chemotherapeutic agents, including paclitaxel (Taxol), involve pro-apoptotic …
Sphingosine-1-phosphate receptor therapies: advances in clinical trials for CNS-related diseases
S O'Sullivan, KK Dev - Neuropharmacology, 2017 - Elsevier
The family of sphingosine-1-phosphate receptors (S1PRs) are G protein-coupled and
comprise of five subtypes, S1P 1-S1P 5. These receptors are activated by the sphingolipid …
comprise of five subtypes, S1P 1-S1P 5. These receptors are activated by the sphingolipid …
Optical control of sphingosine-1-phosphate formation and function
Abstract Sphingosine-1-phosphate (S1P) plays important roles as a signaling lipid in a
variety of physiological and pathophysiological processes. S1P signals via a family of G …
variety of physiological and pathophysiological processes. S1P signals via a family of G …
Chloride–the underrated ion in nociceptors
BU Wilke, KK Kummer, MG Leitner… - Frontiers in neuroscience, 2020 - frontiersin.org
In contrast to pain processing neurons in the spinal cord, where the importance of chloride
conductances is already well established, chloride homeostasis in primary afferent neurons …
conductances is already well established, chloride homeostasis in primary afferent neurons …
microRNAs in nociceptive circuits as predictors of future clinical applications
Neuro-immune alterations in the peripheral and central nervous system play a role in the
pathophysiology of chronic pain, and non-coding RNAs (ncRNAs)–and microRNAs …
pathophysiology of chronic pain, and non-coding RNAs (ncRNAs)–and microRNAs …