After several decades dominated by reductionist approaches in biology, researchers are
returning to the study of complex biology with a litany of new and old techniques—this …

Living organisms have developed a multitude of timing mechanisms—“biological clocks.”
Their mechanisms are based on either oscillations (oscillatory clocks) or unidirectional …

A striking feature of the circadian clock is its flexible yet robust response to various
environmental conditions. To analyze the biochemical processes underlying this flexible-yet …

The flavonoid pathway is known to be up‐regulated by different environmental stress factors.
Down‐regulation of the pathway is much less studied and is emphasized in the present …

Many organisms display rhythms of physiology and behavior that are entrained to the 24-h
cycle of light and darkness prevailing on Earth. Under constant conditions of illumination …

Temperature compensation is a defining feature of circadian oscillators, yet no components
contributing to the phenomenon have been identified in plants. We tested 27 accessions of …

Casein kinase 1 (CK1) plays a central role in regulating the period of the circadian clock. In
mammals, PER2 protein abundance is regulated by CK1-mediated phosphorylation and …

Temperature compensation is an important property of all biological clocks. In Neurospora
crassa, negative-feedback regulation on the frequency (frq) gene's transcription by the FRQ …

To introduce this special issue on biological switches and clocks, we review the historical
development of mathematical models of bistability and oscillations in chemical reaction …

This article focuses on the Goodwin oscillator and related minimal models, which describe
negative feedback schemes that are of relevance for the circadian rhythms in Neurospora …