A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Autophagy is a cellular process in which the cell degrades and recycles its own constituents.
Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is …

The spontaneous contractions of collecting lymphatic vessels provide an essential
propulsive force to return lymph centrally. These contractions are driven by an intrinsic …

In vitro phenotypic assays of sensory neuron activity are important tools for identifying
potential analgesic compounds. These assays are typically characterized by hyperexcitable …

Background/Aims: The roles of intercellular communication and T-type versus L-type voltage-
dependent Ca 2+ channels (VDCCs) in conducted vasoconstriction to local KCl-induced …

For successful fertilization mammalian spermatozoa must undergo the acrosome reaction
(AR), an exocytotic event that allows this cell to penetrate the outer layer of the oocyte, the …

We investigated the role of TRPV4 channels (TRPV4) in regulating the contractility of
detrusor smooth muscle (DSM) and muscularis mucosae (MM) of the urinary bladder …

L-type calcium channel activity has been associated with a number of cytoplasmic
responses, including gene transcription and activation of calcium-dependent enzymes, yet …

T‐type Ca2+ currents have been detected in cells from the external muscular layers of
gastrointestinal smooth muscles and appear to contribute to the generation of pacemaker …

The arterial myogenic response to intraluminal pressure elicits constriction to maintain tissue
perfusion. Smooth muscle [Ca2+] is a key determinant of constriction, tied to L-type (CaV1 …