Signal pathways of melanoma and targeted therapy

W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Immune checkpoint inhibitors in solid organ transplant recipients with advanced skin cancers—Emerging strategies for clinical management

C Ferrándiz-Pulido, U Leiter, C Harwood… - …, 2023 - journals.lww.com
Use of immune checkpoint inhibitors (ICIs) in solid organ transplant recipients (SOTRs) with
advanced skin cancers presents a significant clinical management dilemma. SOTRs and …

[HTML][HTML] The future of targeted kinase inhibitors in melanoma

S Caksa, U Baqai, AE Aplin - Pharmacology & therapeutics, 2022 - Elsevier
Melanoma is a cancer of the pigment-producing cells of the body and its incidence is rising.
Targeted inhibitors that act against kinases in the MAPK pathway are approved for BRAF …

NRF2 and key transcriptional targets in melanoma redox manipulation

EL Carpenter, AL Becker, AK Indra - Cancers, 2022 - mdpi.com
Simple Summary Melanocytes are the pigment-producing cells in the skin that help to
protect it against damaging solar ultraviolet radiation. As they engage in this function, they …

Efficacy of Neoadjuvant Targeted Therapy for Borderline Resectable III BD or IV Stage BRAF V600 Mutation-Positive Melanoma

AM Czarnecka, K Ostaszewski, A Borkowska… - Cancers, 2021 - mdpi.com
Simple Summary Neoadjuvant therapy for locally advanced disease or potentially
resectable metastatic melanoma is expected to improve operability and clinical outcomes …

Real‐world clinical outcome and safety of adjuvant therapy in stage III melanoma patients: Data from two Academic Italian Institutions

V De Falco, G Suarato, R Napolitano… - … Journal of Cancer, 2023 - Wiley Online Library
Adjuvant immunotherapy (IO) and targeted therapy (TT) have improved relapse‐free survival
(RFS) in patients with stage III melanoma, although about 25% of them relapse within a year …

Ulcerated cutaneous melanoma: A review of the clinical, histologic, and molecular features associated with a clinically aggressive histologic phenotype

Z Barricklow, MJ DiVincenzo, CD Angell… - Clinical, Cosmetic and …, 2022 - Taylor & Francis
The presence of ulceration in melanoma is associated with poor clinical outcomes and is the
third most powerful predictor of survival in the AJCC Melanoma Staging System after tumor …

A systematic review with evidence mapping of supportive care interventions for melanoma patients and caregivers

JR Thompson, RA Salam, S Hanna, M Dieng… - Cancer …, 2023 - Wiley Online Library
Aim We conducted a systematic review and evidence gap mapping to explore the existing
supportive care interventions and their impact on well‐being outcomes for melanoma …

Retrospective analysis of adjuvant therapy using dabrafenib plus trametinib in Japanese patients with advanced melanoma: analysis of 36 cases

R Amagai, Y Muto, H Kato, S Matsushita… - Melanoma …, 2021 - journals.lww.com
Patients with resected stage IIIB, IIIC and IIID melanomas have a high risk of recurrence.
Therefore, an appropriate protocol for stage III melanoma is needed. Since adjuvant …

Long‐term efficacy of neoadjuvant–adjuvant targeted therapy in borderline resectable stage IIIB–D and IV melanoma

AM Czarnecka, K Ostaszewski, PJ Błoński… - Cancer, 2024 - Wiley Online Library
Background Neoadjuvant–adjuvant therapy for locally advanced or potentially resectable
metastatic melanoma was expected to improve operability and clinical outcomes over …