Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Apoptosis, necroptosis, and pyroptosis are genetically programmed cell death mechanisms
that eliminate obsolete, damaged, infected, and self-reactive cells. Apoptosis fragments cells …

Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires
the cell-surface protein NINJ1. PMR releases pro-inflammatory cytoplasmic molecules …

Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-
terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD …

The gasdermins are a family of pore-forming proteins that have recently emerged as
executors of pyroptosis, a lytic form of cell death that is induced by the innate immune …

Ferroptosis is a regulated form of necrotic cell death caused by iron-dependent
accumulation of oxidized phospholipids in cellular membranes, culminating in plasma …

Inflammation drives pathology in many human diseases for which there are no disease-
modifying drugs. Inflammasomes are signalling platforms that can induce pathological …

Human airway and corneal epithelial cells, which are critically altered during chronic
infections mediated by Pseudomonas aeruginosa, specifically express the inflammasome …