Taxanes in cancer treatment: Activity, chemoresistance and its overcoming
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
Targeting microtubules by natural agents for cancer therapy
Natural compounds that target microtubules and disrupt the normal function of the mitotic
spindle have proven to be one of the best classes of cancer chemotherapeutic drugs …
spindle have proven to be one of the best classes of cancer chemotherapeutic drugs …
An overview of tubulin inhibitors that interact with the colchicine binding site
Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …
binding site is one of the most important pockets for potential tubulin polymerization …
Microtubules as a target for anticancer drugs
MA Jordan, L Wilson - Nature reviews cancer, 2004 - nature.com
Highly dynamic mitotic-spindle microtubules are among the most successful targets for
anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids …
anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids …
Function-oriented synthesis, step economy, and drug design
PA Wender, VA Verma, TJ Paxton… - Accounts of chemical …, 2008 - ACS Publications
This Account provides an overview and examples of function-oriented synthesis (FOS) and
its increasingly important role in producing therapeutic leads that can be made in a step …
its increasingly important role in producing therapeutic leads that can be made in a step …
Mechanisms of Taxol resistance related to microtubules
GA Orr, P Verdier-Pinard, H McDaid, SB Horwitz - Oncogene, 2003 - nature.com
Since its approval by the FDA in 1992 for the treatment of ovarian cancer, the use of Taxol
has dramatically increased. Although treatment with Taxol has led to improvement in the …
has dramatically increased. Although treatment with Taxol has led to improvement in the …
Antimitotic drugs in the treatment of cancer
RJ van Vuuren, MH Visagie, AE Theron… - Cancer chemotherapy …, 2015 - Springer
Cancer is a complex disease since it is adaptive in such a way that it can promote
proliferation and invasion by means of an overactive cell cycle and in turn cellular division …
proliferation and invasion by means of an overactive cell cycle and in turn cellular division …
[HTML][HTML] Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures
EH Kellogg, NMA Hejab, S Howes, P Northcote… - Journal of molecular …, 2017 - Elsevier
A number of microtubule (MT)-stabilizing agents (MSAs) have demonstrated or predicted
potential as anticancer agents, but a detailed structural basis for their mechanism of action is …
potential as anticancer agents, but a detailed structural basis for their mechanism of action is …
Discovery of novel benzimidazole and indazole analogues as tubulin polymerization inhibitors with potent anticancer activities
Y Ren, Y Wang, G Li, Z Zhang, L Ma… - Journal of Medicinal …, 2021 - ACS Publications
Novel indazole and benzimidazole analogues were designed and synthesized as tubulin
inhibitors with potent antiproliferative activities. Among them, compound 12b exhibited the …
inhibitors with potent antiproliferative activities. Among them, compound 12b exhibited the …
Targeting microtubules for cancer chemotherapy
J Zhou, P Giannakakou - Current Medicinal Chemistry-Anti …, 2005 - ingentaconnect.com
Chemical compounds that interfere with microtubules such as the vinca alkaloids and
taxanes are important chemotherapeutic agents for the treatment of cancer. As our …
taxanes are important chemotherapeutic agents for the treatment of cancer. As our …