Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Abstract Purpose of Review Biomarkers are commonly used in epidemiological studies to
assess metals and metalloid exposure and estimate internal dose, as they integrate multiple …

Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease that inevitably
progress to end-stage kidney disease. Intervention strategies such as blood glucose control …

Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

The mammalian kidney relies on abundant mitochondria in the renal tubule to generate
sufficient ATP to provide the energy required for constant reclamation of solutes from crude …

Renal fibrosis is the common pathological feature in a variety of chronic kidney diseases.
Aging is highly associated with the progression of renal fibrosis. Among several …

FSGS describes a renal histologic lesion with diverse causes and pathogenicities that are
linked by podocyte injury and depletion. Subclasses of FSGS include primary, genetic, and …

With an aging population, kidney health becomes an important medical and socioeconomic
factor. Kidney aging mechanisms are not well understood. We previously showed that …

As human life expectancy keeps increasing, ageing populations present a growing
challenge for clinical practices. Human ageing is associated with molecular, structural, and …

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …