The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters
MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
Urinary pH and stone formation
CA Wagner, N Mohebbi - Journal of nephrology, 2010 - zora.uzh.ch
The formation of various types of kidney stones is strongly influenced by urinary pH. An
alkaline pH favors the crystallization of calcium-and phosphate-containing stones, whereas …
alkaline pH favors the crystallization of calcium-and phosphate-containing stones, whereas …
Mechanisms of metabolic acidosis–induced kidney injury in chronic kidney disease
DE Wesson, JM Buysse… - Journal of the American …, 2020 - journals.lww.com
Retrospective analyses and single-center prospective studies identify chronic metabolic
acidosis as an independent and modifiable risk factor for progression of CKD. In patients …
acidosis as an independent and modifiable risk factor for progression of CKD. In patients …
The genomic analysis of lactic acidosis and acidosis response in human cancers
JLY Chen, JE Lucas, T Schroeder, S Mori, J Wu… - PLoS …, 2008 - journals.plos.org
The tumor microenvironment has a significant impact on tumor development. Two important
determinants in this environment are hypoxia and lactic acidosis. Although lactic acidosis …
determinants in this environment are hypoxia and lactic acidosis. Although lactic acidosis …
Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis
Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic
organs, sickle cell disease, and many other pathological conditions due to hypoxia …
organs, sickle cell disease, and many other pathological conditions due to hypoxia …
Regulation of phosphate transport in proximal tubules
J Biber, N Hernando, I Forster, H Murer - Pflügers Archiv-European Journal …, 2009 - Springer
Homeostasis of inorganic phosphate (P i) is primarily an affair of the kidneys. Reabsorption
of the bulk of filtered P i occurs along the renal proximal tubule and is initiated by apically …
of the bulk of filtered P i occurs along the renal proximal tubule and is initiated by apically …
Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family
AM Pajor - Pflügers Archiv-European Journal of Physiology, 2014 - Springer
The SLC13 family in humans and other mammals consists of sodium-coupled transporters
for anionic substrates: three transporters for dicarboxylates/citrate and two transporters for …
for anionic substrates: three transporters for dicarboxylates/citrate and two transporters for …
Regulated acid–base transport in the collecting duct
The renal collecting system serves the fine-tuning of renal acid–base secretion. Acid-
secretory type-A intercalated cells secrete protons via a luminally expressed V-type H+ …
secretory type-A intercalated cells secrete protons via a luminally expressed V-type H+ …
Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway
A Chen, L Dong, NR Leffler, AS Asch, ON Witte… - PloS one, 2011 - journals.plos.org
Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue
microenvironments are often acidic at inflammatory sites, the mechanisms by which cells …
microenvironments are often acidic at inflammatory sites, the mechanisms by which cells …
Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA
Although lactic acidosis is a prominent feature of solid tumors, we still have limited
understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes …
understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes …