How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution

EA Groisman, A Duprey, J Choi - Microbiology and Molecular …, 2021 - Am Soc Microbiol
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …

Long chain fatty acids and virulence repression in intestinal bacterial pathogens

MK Mitchell, M Ellermann - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
When bacterial pathogens enter the gut, they encounter a complex milieu of signaling
molecules and metabolites produced by host and microbial cells or derived from external …

Lysine acetylation regulates the AT-rich DNA possession ability of H-NS

Y Liu, M Zhou, Y Bu, L Qin, Y Zhang… - Nucleic Acids …, 2024 - academic.oup.com
H-NS, the histone-like nucleoid-structuring protein in bacteria, regulates the stability of the
bacterial genome by inhibiting the transcription of horizontally transferred genes, such as the …

Post-translational lysine ac (et) ylation in bacteria: A biochemical, structural, and synthetic biological perspective

M Lammers - Frontiers in Microbiology, 2021 - frontiersin.org
Ac (et) ylation is a post-translational modification present in all domains of life. First identified
in mammals in histones to regulate RNA synthesis, today it is known that is regulates …

Global Acetylomics of Campylobacter jejuni Shows Lysine Acetylation Regulates CadF Adhesin Processing and Human Fibronectin Binding

AL Dale, L Man, SJ Cordwell - Journal of Proteome Research, 2023 - ACS Publications
Lysine acetylation (KAc) is a reversible post-translational modification (PTM) that can alter
protein structure and function; however, specific roles for KAc are largely undefined in …

Acetylation of NarL K188 and K192 is involved in regulating Escherichia coli anaerobic nitrate respiration

SS Cai, LQ Zhang, Q Zhang, BC Ye, Y Zhou - Applied Microbiology and …, 2022 - Springer
As a facultative anaerobe, Escherichia coli can activate various respiratory chains during
anaerobic growth, among which the mode of anaerobic respiration with nitrate allows good …

[HTML][HTML] Propionylation of lysine, a new mechanism of short-chain fatty acids affecting bacterial virulence

H Tang, Z Zhan, Y Zhang, X Huang - American Journal of …, 2022 - ncbi.nlm.nih.gov
Propionic acid (PA) is a major component of short-chain fatty acids produced by
Bacteroidetes spp. Lysine propionylation is a novel type of protein regulatory …

Integrated mass spectrometry-based multi-omics for elucidating mechanisms of bacterial virulence

L Man, WP Klare, AL Dale, JA Cain… - Biochemical Society …, 2021 - portlandpress.com
Despite being considered the simplest form of life, bacteria remain enigmatic, particularly in
light of pathogenesis and evolving antimicrobial resistance. After three decades of …

Critical role of msgA in invasive capacity and intracellular survivability of Salmonella

X Liu, C Wang, W Gai, Z Sun, L Fang… - Applied and …, 2024 - journals.asm.org
Salmonella enterica serovar Typhimurium, which is a common foodborne pathogen, causes
both intestinal and systemic infections in hosts. Salmonella has a complex pathogenic …

Involvement of PhoP/PhoQ two-component system in biofilm formation in Cronobacter sakazakii

Y Ma, Y Zhang, Z Shan, X Wang, X Xia - Food Control, 2022 - Elsevier
The aim of this study was to investigated the effect of PhoP/PhoQ two component system on
the biofilm formation of Cronobacter sakazakii BAA-894. Crystal violet staining assay and …