New strategies for a sustainable 99mTc supply to meet increasing medical demands: Promising solutions for current problems

MF Nawar, A Türler - Frontiers in chemistry, 2022 - frontiersin.org
The continuing rapid expansion of 99mTc diagnostic agents always calls for scaling up
99mTc production to cover increasing clinical demand. Nevertheless, 99mTc availability …

Unparalleled contribution of technetium-99m to medicine over 5 decades

WC Eckelman - JACC: Cardiovascular Imaging, 2009 - jacc.org
Since the first tracer study by George C. de Hevesy in 1923, in which he used the tracer
principle to study the absorption and translocation of lead nitrate with Pb-212 (1) …

Sustained availability of 99mTc: possible paths forward

MRA Pillai, A Dash, FFR Knapp - Journal of Nuclear Medicine, 2013 - Soc Nuclear Med
The availability of 99mTc for single-photon imaging in diagnostic nuclear medicine is crucial,
and current availability is based on the 99Mo/99mTc generator fabricated from fission-based …

Identification of ubiquitously present polymeric adlayers on 2D transition metal dichalcogenides

R Tilmann, C Bartlam, O Hartwig, B Tywoniuk… - ACS …, 2023 - ACS Publications
The interest in 2D materials continues to grow across numerous scientific disciplines as
compounds with unique electrical, optical, chemical, and thermal characteristics are being …

Cyclotron production of 99mTc: experimental measurement of the 100Mo (p, x) 99Mo, 99mTc and 99gTc excitation functions from 8 to 18 MeV

K Gagnon, F Bénard, M Kovacs, TJ Ruth… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: The cyclotron-based 100Mo (p, 2n) 99mTc transformation has been
proposed as a viable alternative to the reactor based 235U (n, f) 99Mo→ 99mTc strategy for …

Evaluation of excitation functions of 100Mo (p, d+ pn) 99Mo and 100Mo (p, 2n) 99mTc reactions: estimation of long-lived Tc-impurity and its implication on the specific …

SM Qaim, S Sudár, B Scholten, AJ Koning… - Applied Radiation and …, 2014 - Elsevier
Excitation functions were calculated by the code TALYS for 10 proton-induced reactions on
100 Mo. For 100 Mo (p, d+ pn) 99 Mo and 100 Mo (p, 2n) 99m Tc, calculations were also …

The present and future of medical radionuclide production

SM Qaim - Radiochimica Acta, 2012 - degruyter.com
Medical radionuclide production technology is well established. Both reactors and
cyclotrons are utilized for production; the positron emitters, however, are produced …

Medical isotope production without highly enriched uranium

National Research Council, Life Studies… - 2009 - books.google.com
This book is the product of a congressionally mandated study to examine the feasibility of
eliminating the use of highly enriched uranium (HEU2) in reactor fuel, reactor targets, and …

Implementation of multi-curie production of 99mTc by conventional medical cyclotrons

F Bénard, KR Buckley, TJ Ruth, SK Zeisler… - Journal of Nuclear …, 2014 - Soc Nuclear Med
99mTc is currently produced by an aging fleet of nuclear reactors, which require enriched
uranium and generate nuclear waste. We report the development of a comprehensive …

Recommended nuclear data for medical radioisotope production: diagnostic gamma emitters

FT Tárkányi, AV Ignatyuk, A Hermanne… - … of Radioanalytical and …, 2019 - Springer
An extensive series of evaluations have been performed as part of an IAEA coordinated
research project to study a set of nuclear reactions that produce the diagnostic gamma-ray …