Anti-Staphylococcus Aureus Effects of Natural Antimicrobial Peptides and the Underlying Mechanisms

X Chen, J Yang, C Qu, Q Zhang, S Sun, L Liu - Future Microbiology, 2024 - Taylor & Francis
Staphylococcus aureus can cause localized infections such as abscesses and pneumonia,
as well as systemic infections such as bacteremia and sepsis. Especially, methicillin …

A Novel Peptide Antibiotic Produced by Streptomyces roseoflavus Strain INA-Ac-5812 With Directed Activity Against Gram-Positive Bacteria

AS Vasilchenko, WT Julian, OA Lapchinskaya… - Frontiers in …, 2020 - frontiersin.org
In this work, we report the isolation and detailed functional characterization for the new non-
ribosomally synthesized antibiotic 5812-A/C, which was derived from metabolites of …

Gausemycins A,B: Cyclic Lipoglycopeptides from Streptomyces sp.**

AP Tyurin, VA Alferova, AS Paramonov… - Angewandte Chemie …, 2021 - Wiley Online Library
We report a novel family of natural lipoglycopeptides produced by Streptomyces sp. INA‐Ac‐
5812. Two major components of the mixture, named gausemycins A and B, were isolated …

Staphylococcus aureus is able to generate resistance to novel lipoglycopeptide antibiotic gausemycin A

DV Poshvina, DS Dilbaryan, SP Kasyanov… - Frontiers in …, 2022 - frontiersin.org
Gausemycin A is the first member of the novel lipoglycopeptides family produced by
Streptomyces roseoflavus INA-Ac-5812. Gausemycin A has a pronounced bactericidal …

Gausemycin Antibiotic Family Acts via Ca2+-Dependent Membrane Targeting

TV Kravchenko, AS Paramonov… - Journal of Natural …, 2024 - ACS Publications
We report the molecular mechanism of action of gausemycins and the isolation of new
members of the family, gausemycins C (1c), D (1d), E (1e), and F (1f), the minor components …

A novel trityl/acridine derivatization agent for analysis of thiols by (matrix-assisted)(nanowire-assisted) laser desorption/ionization and electrospray ionization mass …

AP Topolyan, MA Belyaeva, MS Slyundina… - Analytical …, 2017 - pubs.rsc.org
The derivatization reagent was prepared in situ by the reaction of tris (2, 6-dimethoxyphenyl)
methylium hexafluorophosphate with N-(2-aminoethyl) maleimide and used for the …

4-Chloro-l-kynurenine as fluorescent amino acid in natural peptides

VA Alferova, MV Shuvalov, TA Suchkova, GV Proskurin… - Amino Acids, 2018 - Springer
Chloro-l-kynurenine (3-(4-chloroanthraniloyl)-l-alanine, l-4-ClKyn), an amino acid known as
a prospective antidepressant, was recently for the first time found in nature in the lipopeptide …

Structure, 1H and 13C NMR spectra of the minor component from the antimicrobial complex produced by actinomycete Streptomyces roseoflavus (INA-Ac-5812)

DE Tsvetkov, AO Chizhov, AS Dmitrenok… - Russian Chemical …, 2023 - Springer
The antibiotics INA-5812, produced by the strain INA-Ac-5812 of Streptomyces roseoflavus
have pronounced antibacterial and chemotherapeutic activity and low value of acute toxicity …

Structure-activity studies of irumamycin type macrolides from Streptomyces sp. INA-Ac-5812

VA Alferova, MV Shuvalov, RA Novikov, AS Trenin… - Tetrahedron …, 2019 - Elsevier
Three natural glycosylated macrolide compounds, known irumamycin 1 and X-14952B 2, as
well as new isoirumamycin 3, were isolated from ethyl acetate mycelium extract of …

Generation of Gausemycin A-resistant Staphylococcus aureus

DV Poshvina, DS Dilbaryan, SP Kasyanov… - bioRxiv, 2022 - biorxiv.org
Gausemycins A and B are the first members of the novel lipoglycopeptides family produced
by Streptomyces roseoflavus INA-Ac-5812, which showed the ability to fight clinically …