The'invisible hand'is a term originally coined by Adam Smith in The Theory of Moral
Sentiments to describe the forces of self-interest, competition and supply and demand that …

Advances in genomics, proteomics and molecular pathology have generated many
candidate biomarkers with potential clinical value. Their use for cancer staging and …

Rho GTPases contribute to multiple cellular processes that could affect cancer progression,
including cytoskeletal dynamics, cell cycle progression, transcriptional regulation, cell …

Deciphering the cellular and molecular interactions that drive disease within the tissue
microenvironment holds promise for discovering drug targets of the future. In order to …

The ability of physicians to effectively treat and cure cancer is directly dependent on their
ability to detect cancers at their earliest stages. Proteomic analyses of early-stage cancers …

The ability to sequence whole genomes has taught us that our knowledge with respect to
gene function is rather limited with typically 30–40% of open reading frames having no …

The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases.
To date, 22 human genes encoding at least 25 proteins have been described. The best …

The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs
control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and …

Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal-
physiological substrates of glyoxalase 1-iso potentially damaging to the proteome, genome …

Ovarian cancer is characterize by few early symptoms, presentation at an advanced stage,
and poor survival. As a result, it is the most frequent cause of death from gynecological …