The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

A Rutsch, JB Kantsjö, F Ronchi - Frontiers in immunology, 2020 - frontiersin.org
The human microbiota has a fundamental role in host physiology and pathology. Gut
microbial alteration, also known as dysbiosis, is a condition associated not only with …

[HTML][HTML] Role of microbiota-derived short-chain fatty acids in nervous system disorders

R Mirzaei, B Bouzari, SR Hosseini-Fard… - Biomedicine & …, 2021 - Elsevier
During the past decade, accumulating evidence from the research highlights the suggested
effects of bacterial communities of the human gut microbiota and their metabolites on health …

Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms

ZD Wallen, A Demirkan, G Twa, G Cohen… - Nature …, 2022 - nature.com
Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …

Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 …

Z Zhao, J Ning, X Bao, M Shang, J Ma, G Li, D Zhang - Microbiome, 2021 - Springer
Background Parkinson's disease (PD) is a prevalent neurodegenerative disorder, displaying
not only well-known motor deficits but also gastrointestinal dysfunctions. Consistently, it has …

Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation

S Romano, GM Savva, JR Bedarf, IG Charles… - npj Parkinson's …, 2021 - nature.com
The gut microbiota is emerging as an important modulator of neurodegenerative diseases,
and accumulating evidence has linked gut microbes to Parkinson's disease (PD) …

The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health

JL Waters, RE Ley - BMC biology, 2019 - Springer
The Christensenellaceae, a recently described family in the phylum Firmicutes, is emerging
as an important player in human health. The relative abundance of Christensenellaceae in …

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

V Maini Rekdal, EN Bess, JE Bisanz, PJ Turnbaugh… - Science, 2019 - science.org
INTRODUCTION Parkinson's disease is a debilitating neurological condition affecting more
than 1% of the global population aged 60 and above. The primary medication used to treat …

[HTML][HTML] Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort

P Liu, L Wu, G Peng, Y Han, R Tang, J Ge… - Brain, behavior, and …, 2019 - Elsevier
Abstract Objective (Background): Alzheimer's disease (AD), clinically characterized by the
progressive neurodegenerative condition and cognitive impairment, is one of the main …

Fecal microbiota transplantation alleviated Alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice

J Sun, J Xu, Y Ling, F Wang, T Gong, C Yang… - Translational …, 2019 - nature.com
Alzheimer's disease (AD) is the most common dementia in the elderly. Treatment for AD is
still a difficult task in clinic. AD is associated with abnormal gut microbiota. However, little is …

The association between the gut microbiota and Parkinson's disease, a meta-analysis

T Shen, Y Yue, T He, C Huang, B Qu, W Lv… - Frontiers in aging …, 2021 - frontiersin.org
Patients with Parkinson's disease (PD) were often observed with gastrointestinal symptoms,
which preceded the onset of motor symptoms. Neuropathology of PD has also been found in …