The cytoskeleton is the major mechanical structure of the cell; it is a complex, dynamic
biopolymer network comprising microtubules, actin, and intermediate filaments. Both the …

One of the most intriguing protein materials found in nature is bone, a material composed of
assemblies of tropocollagen molecules and tiny hydroxyapatite mineral crystals that form an …

We report two generative deep-learning models that predict amino acid sequences and 3D
protein structures on the basis of secondary-structure design objectives via either the overall …

Intermediate filaments (IFs) are integral components of the cytoskeleton. They provide cells
with tissue-specific mechanical properties and are involved in numerous cellular processes …

The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous
proteins, F-actin, microtubules, and intermediate filaments. Interactions among the …

In this work, we investigate whether stiffening in compression is a feature of single cells and
whether the intracellular polymer networks that comprise the cytoskeleton (all of which stiffen …

The mechanical properties of a cell determine many aspects of its behavior, and these
mechanics are largely determined by the cytoskeleton. Although the contribution of actin …

Fibrin is a protein polymer that forms the viscoelastic scaffold of blood clots and thrombi.
Despite the critical importance of fibrin deformability for outcomes of bleeding and …

Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

The mechanical properties of cells are important in tissue homeostasis and enable cell
growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties …