Fluoropyrimidines are chemotherapeutic agents widely used for the treatment of various
solid tumors. Commonly prescribed FPs include 5-fluorouracil (5-FU) and its oral prodrugs …

Background & Aims Vitamin D exerts regulatory roles via vitamin D receptor (VDR) in
mucosal immunity, host defense, and inflammation involving host factors and microbiome …

Adverse events affect the pharmacological treatment of approximately 90% of colorectal
cancer (CRC) patients at any stage of the disease. Chemotherapy including …

The microbiota plays critical roles in regulating the function and health of the intestine and
extraintestinal organs. A fundamental question is whether an intestinal-microbiome-breast …

Simple Summary There is an increasing scientific interest in the study of the interaction
between the immune system and drugs in cancer that can affect the efficacy of an anti …

Pharmacogenetics plays a key role in personalized cancer treatment. Currently, the clinically
available pharmacogenetic markers for metastatic colorectal cancer (mCRC) are in genes …

Introduction Irinotecan is a cytotoxic agent that is widely used in the treatment of several
types of solid tumors. However, although it is generally well tolerated, approximately 20% to …

The introduction of anti-EGFR (cetuximab and panitumumab) and antiangiogenic
(bevacizumab, regorafeninb, ramucirumab, and aflibercept) agents in the therapeutic …

Nuclear receptors act as mediators of cancer-related inflammation and gene expression.
They have a regulatory effect on genes encoding proteins related to drug adsorption …

Neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery is the standard of care
for patients with Locally Advanced Rectal Cancer (LARC). Current selection for nCRT is …