Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

The voltage-gated sodium channel NaV1. 7 is preferentially expressed in peripheral somatic
and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Epilepsy is a disease characterized by abnormal brain activity and a predisposition to
generate epileptic seizures, leading to neurobiological, cognitive, psychological, social, and …

Painful peripheral neuropathy often occurs without apparent underlying cause. Gain-of-
function variants of sodium channel Nav1. 7 have recently been found in∼ 30% of cases of …

Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Nav1. 1–Nav1. 9, are …

Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium
channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …