Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms

GH Oliveira-Paula, R Lacchini, JE Tanus-Santos - Gene, 2016 - Elsevier
Nitric oxide (NO) is an important vasodilator with a well-established role in cardiovascular
homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and …

Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?

SP Guan, RCS Seet, BK Kennedy - Ageing Research Reviews, 2020 - Elsevier
The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly.
The molecular mechanisms underpinning the age-dependent disparity for disease …

[HTML][HTML] Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases

GH Oliveira-Paula, R Lacchini, JE Tanus-Santos - Nitric Oxide, 2017 - Elsevier
Nitric oxide (NO) is a vasoactive substance synthesized from l-arginine by neuronal (NOS1),
endothelial (NOS3), and inducible (NOS2) nitric oxide synthases. NOS3 is the most …

Association of endothelial nitric oxide synthase 894G> T polymorphism with preeclampsia risk: a systematic review and meta-analysis based on 35 studies

H Abbasi, SA Dastgheib, A Hadadan… - Fetal and pediatric …, 2021 - Taylor & Francis
Background Several case–control studies have been performed to investigate the
association between 894 G> T polymorphism in endothelial nitric oxide synthase (eNOS) …

Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia

VC Sandrim, ACT Palei, JT Sertorio… - Molecular human …, 2010 - academic.oup.com
Pre-eclampsia (PE) is associated with decreased nitric oxide (NO) formation. However, no
previous study has examined whether genetic variations in the endothelial NO synthase …

Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population

TM da Silva, AV Rocha, R Lacchini, CR Marques… - Gene, 2012 - Elsevier
The present study aimed to investigate the association of endothelial nitric oxide synthase
(eNOS) gene polymorphisms with primary open angle glaucoma (POAG). We conducted a …

[HTML][HTML] Endothelial nitric oxide synthase polymorphisms and susceptibility to high-tension primary open-angle glaucoma in an Egyptian cohort

WA Emam, HE Zidan, BEH Abdulhalim… - Molecular …, 2014 - ncbi.nlm.nih.gov
Purpose To analyze the association of polymorphisms of the endothelial nitric oxide
synthase (NOS3) gene and nitric oxide (NO) levels with high-tension primary open-angle …

Interaction among nitric oxide (NO)-related genes in migraine susceptibility

FM Gonçalves, MR Luizon, JG Speciali… - Molecular and cellular …, 2012 - Springer
The pathogenic mechanisms involved in migraine are complex and not completely clarified.
Because there is evidence for the involvement of nitric oxide (NO) in migraine …

Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy

MR Luizon, VC Sandrim, ACT Palei, R Lacchini… - Hypertension …, 2012 - nature.com
Polymorphisms of the endothelial nitric oxide synthase (eNOS), matrix metalloproteinase-9
(MMP-9) and vascular endothelial growth factor (VEGF) genes were shown to be associated …

Pharmacogenetic relevance of endothelial nitric oxide synthase polymorphisms and gene interactions

MR Luizon, DA Pereira, JE Tanus-Santos - Pharmacogenomics, 2018 - Taylor & Francis
Endothelial nitric oxide synthase (NOS3) is a key enzyme responsible for nitric oxide (NO)
generation in the vascular endothelium. Endothelial dysfunction is characterized by reduced …