Digital twins and automation of care in the intensive care unit
Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …
multiplied by increasing incidence of chronic diseases and decreasing available funding …
Virtual patients for mechanical ventilation in the intensive care unit
Background Mechanical ventilation (MV) is a core intensive care unit (ICU) therapy.
Significant inter-and intra-patient variability in lung mechanics and condition makes …
Significant inter-and intra-patient variability in lung mechanics and condition makes …
Over-distension prediction via hysteresis loop analysis and patient-specific basis functions in a virtual patient model
Background and objective Recruitment maneuvers (RMs) with subsequent positive-end-
expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing …
expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing …
Model-based estimation of negative inspiratory driving pressure in patients receiving invasive NAVA mechanical ventilation
Background Optimisation of mechanical ventilation (MV) and weaning requires insight into
underlying patient breathing effort. Current identifiable models effectively describe lung …
underlying patient breathing effort. Current identifiable models effectively describe lung …
Network data acquisition and monitoring system for intensive care mechanical ventilation treatment
The rise of model-based and machine learning methods have created increasingly realistic
opportunities to implement personalized, patient-specific mechanical ventilation (MV) in the …
opportunities to implement personalized, patient-specific mechanical ventilation (MV) in the …
Model based care in the ICU: A review of potential combined cardio-pulmonary models
Positive end-expiratory pressure results in a sustained positive intrathoracic pressure, which
exerts pressure on intrathoracic vessels, resulting in cardiopulmonary interactions. This …
exerts pressure on intrathoracic vessels, resulting in cardiopulmonary interactions. This …
Digital twins in critical care: what, when, how, where, why?
Healthcare and intensive care unit (ICU) medicine in particular, are facing a devastating
tsunami of rising demand multiplied by increasing chronic disease and aging demographics …
tsunami of rising demand multiplied by increasing chronic disease and aging demographics …
Whole-lung finite-element models for mechanical ventilation and respiratory research applications
N Avilés-Rojas, DE Hurtado - Frontiers in Physiology, 2022 - frontiersin.org
Mechanical ventilation has been a vital treatment for Covid-19 patients with respiratory
failure. Lungs assisted with mechanical ventilators present a wide variability in their …
failure. Lungs assisted with mechanical ventilators present a wide variability in their …
Prediction and estimation of pulmonary response and elastance evolution for volume-controlled and pressure-controlled ventilation
Mechanical ventilation (MV) is a core treatment for patients suffering from respiratory
disease and failure. However, MV settings are not standardized due to significant inter-and …
disease and failure. However, MV settings are not standardized due to significant inter-and …
An approach to study recruitment/derecruitment dynamics in a patient‐specific computational model of an injured human lung
CM Geitner, T Becher, I Frerichs… - International Journal …, 2023 - Wiley Online Library
We present a new approach for physics‐based computational modeling of diseased human
lungs. Our main object is the development of a model that takes the novel step of …
lungs. Our main object is the development of a model that takes the novel step of …