How cells become malignant has preoccupied scientists for over a century. However, the
converse question is also valid: are tumour cells capable of reverting from their malignant …

The translationally controlled tumor protein (TCTP) is a highly conserved protein present in
eukaryotic organisms. This protein, located both in the cytoplasmic and the nucleus, is …

Abstract The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called
P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein …

The oocyte is the only cell of the body that can reprogram transplanted somatic nuclei and
sets the gold standard for all reprogramming methods. Therefore, an in-depth …

Abstract In women, up to 99.9% of the oocyte stockpile formed during fetal life is decimated
by apoptosis. Apoptotic features are also detected in human preimplantation embryos both …

Background The mature mouse oocyte contains the full complement of maternal proteins
required for fertilization, reprogramming, zygotic gene activation (ZGA), and the early stages …

Embryonic stem (ES) cells have therapeutic potential in regenerative medicine, although the
molecular mechanism controlling their pluripotency is not completely understood …

Nuclear transfer has been regarded as the only reliable tool for studying nuclear
reprogramming of mammalian somatic cells by oocytes. However, nuclear transfer is not …

Proper regulation of transcription is essential for cells to acquire and maintain cell identity.
Transcriptional activation plays a central role in gene regulation and can be modulated by …

Translationally controlled tumor-associated protein (TCTP) is a ubiquitous and highly
conserved protein implicated in cancers. Here, we demonstrate that interactions of TCTP …