[HTML][HTML] The role of splicing factors in adipogenesis and thermogenesis
Obesity is a significant global health risk that can cause a range of serious metabolic
problems, such as type 2 diabetes and cardiovascular diseases. Adipose tissue plays a …
problems, such as type 2 diabetes and cardiovascular diseases. Adipose tissue plays a …
[HTML][HTML] Pre-RNA splicing in metabolic homeostasis and liver disease
AM Jobbins, S Yu, HAB Paterson, H Maude… - Trends in Endocrinology …, 2023 - cell.com
The liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic
homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their …
homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their …
The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma
C Chang, M Rajasekaran, Y Qiao, H Dong… - Nature …, 2022 - nature.com
Deregulation of alternative splicing is implicated as a relevant source of molecular
heterogeneity in cancer. However, the targets and intrinsic mechanisms of splicing in …
heterogeneity in cancer. However, the targets and intrinsic mechanisms of splicing in …
Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The
mechanisms regulating liver-specific AS profiles and their contribution to liver function are …
mechanisms regulating liver-specific AS profiles and their contribution to liver function are …
SRSF2 regulates alternative splicing to drive hepatocellular carcinoma development
C Luo, Y Cheng, Y Liu, L Chen, L Liu, N Wei, Z Xie… - Cancer research, 2017 - AACR
Aberrant RNA splicing is recognized to contribute to cancer pathogenesis, but the
underlying mechanisms remain mainly obscure. Here, we report that the splicing factor …
underlying mechanisms remain mainly obscure. Here, we report that the splicing factor …
SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway
X Liu, S Shen, L Zhu, R Su, J Zheng, X Ruan… - Journal of Experimental …, 2020 - Springer
Background Angiogenesis plays an important role in the progress of glioma. RNA-binding
proteins (RBPs) and circular RNAs (circRNAs), dysregulated in various tumors, have been …
proteins (RBPs) and circular RNAs (circRNAs), dysregulated in various tumors, have been …
PPARγΔ5, a naturally occurring dominant-negative splice isoform, impairs PPARγ function and adipocyte differentiation
Peroxisome-proliferator-activated receptor γ (PPARγ) regulates glucose and lipid
homeostasis, insulin signaling, and adipocyte differentiation. Here, we report the skipping of …
homeostasis, insulin signaling, and adipocyte differentiation. Here, we report the skipping of …
Diversification of the muscle proteome through alternative splicing
K Nakka, C Ghigna, D Gabellini, FJ Dilworth - Skeletal muscle, 2018 - Springer
Background Skeletal muscles express a highly specialized proteome that allows the
metabolism of energy sources to mediate myofiber contraction. This muscle-specific …
metabolism of energy sources to mediate myofiber contraction. This muscle-specific …
Insights into established and emerging roles of SR protein family in plants and animals
Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …
Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis
Conclusions: These studies reveal that (1) the regulation of alternative splicing by SRPK2 is
implicated in lipogenesis in humans with ALD;(2) FGF21 is a key hepatokine that …
implicated in lipogenesis in humans with ALD;(2) FGF21 is a key hepatokine that …