Background: Aspirin for prevention of colorectal cancer is controversial. Purpose: To
examine the benefits and harms of aspirin chemoprevention. Data Sources: MEDLINE, 1966 …

This article describes methods used to estimate parameters governing long-term survival, or
times to other events, for health economic models. Specifically, the focus is on methods that …

Background This guideline focuses on long-term administration of antithrombotic drugs
designed for primary and secondary prevention of cardiovascular disease, including two …

Abstract Aims Whilst the CArdiac REsynchronization in Heart Failure (CARE-HF) trial has
shown that cardiac resynchronization therapy (CRT) leads to reduced morbidity and …

Background Aspirin is the prophylactic antiplatelet drug of choice for people with
cardiovascular disease. Adding a second antiplatelet drug to aspirin may produce additional …

Summary Abstract Clopidogrel (Plavix®, Iscover®) selectively and irreversibly inhibits
adenosine diphosphate (ADP)-induced platelet aggregation. Long-term administration of …

Objective To estimate the incidence and HRs for bleeding for different dual antiplatelet
therapies (DAPT) in a real-world population with acute coronary syndrome (ACS) …

Purpose This study aimed to examine the cost-effectiveness of CYP2C19 loss-of-function
and gain-of-function allele guided (LOF/GOF-guided) antiplatelet therapy in patients with …

Objetivo Evaluar la carga de enfermedad asociada al consumo de tabaco en Argentina y
estimar el impacto sanitario y económico de aumentos de precio en los cigarrillos a través …

Aim: This study aimed to compare the clinical and economic outcomes of pharmacogenetic-
guided (PG-guided) and platelet reactivity testing-guided antiplatelet therapy for patients …