Acquired chromosome aberrations are present in the marrow of most patients with acute
myeloid leukaemia (AML) at diagnosis. Cytogenetically, AML is a very heterogeneous …

Despite its clinical and histological heterogeneity, anaplastic large cell lymphoma (ALCL) is
now a well-recognized clinicopathological entity accounting for 2% of all adult non …

We have developed a statistical regression modeling approach to discover genes that are
differentially expressed between two predefined sample groups in DNA microarray …

Promyelocytic leukemia nuclear bodies (PML-NBs) are nuclear structures that accumulate
intrinsic host factors to restrict viral infections. To ensure viral replication, these must be …

RasGRP represents the prototype of a new class of guanine nucleotide exchange factors
that activate small GTPases. The guanyl nucleotide-releasing protein (GRP) family members …

We have previously demonstrated that acquisition of intricate patterns of activating
(H3K4me3, H3K9/K14ac) and repressive (H3K27me3) histone modifications is a hallmark of …

Abstract The E1B-55K product from human adenovirus is a substrate of the small ubiquitin-
related modifier (SUMO)-conjugation system. SUMOylation of E1B-55K is required to …

ABSTRACT PML nuclear bodies (PML NBs), also called ND10, are matrix-bound nuclear
structures that have been implicated in a variety of functions, including DNA repair …

Neutrophil granulocytes (Gs) represent highly abundant and short-lived leukocytes that are
constantly regenerated from a small pool of myeloid committed progenitors. Nuclear …

Although modulation of the cellular tumor-suppressor p53 is considered to have the major
role in E1A/E1B-55K-mediated tumorigenesis, other promyelocytic leukemia nuclear body …