Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Studies of cellular mechanotransduction have converged upon the idea that cells sense
extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on …

Cell cultures are important material of study for the variety of advantages that they offer. Both
established continuous cell lines and primary cell cultures continue to be invaluable for …

Tissue development is orchestrated by the coordinated activities of both chemical and
physical regulators. While much attention has been given to the role that chemical regulators …

The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …