Recent progress in anticancer agents incorporating pyrazole scaffold

S Mor, M Khatri, R Punia… - Mini Reviews in Medicinal …, 2022 - benthamdirect.com
The search for new anticancer agents is considered a dynamic field of medicinal chemistry.
In recent years, the synthesis of compounds with anticancer potential has increased and a …

Pyrazolines: a biological review

A Marella, R Ali, T Alam, R Saha… - Mini reviews in …, 2013 - ingentaconnect.com
Pyrazoline is an important five membered nitrogen heterocycle, which has been extensively
researched upon. The ring is quite stable and has inspired chemists to carry out various …

GABA allosteric modulators: an overview of recent developments in non-benzodiazepine modulators

VR Solomon, VJ Tallapragada, M Chebib… - European journal of …, 2019 - Elsevier
Abstract γ-Aminobutyric acid (GABA) is the major inhibitory transmitter controlling synaptic
transmission and neuronal excitability. It is present in a high percentage of neurons in the …

Synthesis, characterization and anticancer screening of some novel piperonyl–tetrazole derivatives

M Arshad, AR Bhat, S Pokharel, JE Kim, EJ Lee… - European journal of …, 2014 - Elsevier
Abstract A series of new 1, 2-substituted tetrazole derivatives were synthesized and
evaluated on MCF-7 (ER positive), MDA-MB-231 and ZR-75 (ER negative) breast cancer …

Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti …

H Kothayer, S Rezq, AS Abdelkhalek… - Journal of Enzyme …, 2023 - Taylor & Francis
We designed and synthesised novel quinazolinone tethered phenyl urea derivatives (6a–p)
that triple target the double mutant EGFRL858R/T790M, COX-2, and 15-LOX. Compounds …

Vibrational spectroscopic studies, Fukui functions, HOMO-LUMO, NLO, NBO analysis and molecular docking study of (E)-1-(1, 3-benzodioxol-5-yl)-4, 4-dimethylpent-1 …

RI Al-Wabli, KS Resmi, YS Mary, CY Panicker… - Journal of Molecular …, 2016 - Elsevier
Abstract The FT-IR and FT-Raman spectra of (E)-1-(1, 3-benzodioxol-5-yl)-4, 4-dimethylpent-
1-en-3-one were recorded and analyzed experimentally and theoretically. The observed …

A new insight into the synthesis and biological activities of pyrazole based derivatives

S Mor, M Khatri, R Punia, S Nagoria… - Mini-Reviews in …, 2022 - ingentaconnect.com
This review aims to collate literature work reported by researchers (from 1994 to 2021) to
provide an overview of the available methodologies for the synthesis and diverse …

Production of (R)‐1‐(1,3‐benzodioxol‐5‐yl)ethanol in high enantiomeric purity by Lactobacillus paracasei BD101

E Şahin - Chirality, 2018 - Wiley Online Library
Piperonyl ring is found in a number of naturally occurring compounds and possesses
enormous biological activities. There are many studies in the literature with compounds …

Anticonvulsant Classes and Possible Mechanism of Actions

WH Abd-Allah, MA El-Mohsen Anwar… - ACS Chemical …, 2023 - ACS Publications
Epilepsy is considered one of the most common neurological disorders worldwide; it needs
long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs …

Pyrazoline: A promising scaffold for the inhibition of monoamine oxidase

B Mathew, J Suresh, S Anbazhagan… - … System Agents in …, 2013 - ingentaconnect.com
In the five membered nitrogen containing heterocyclic family, pyrazoline could be
recognized as a promising scaffold for the inhibition of Monoamine oxidase. Substitution at …