The puzzling mutational landscape of the SARS‐2‐variant Omicron

J Fantini, N Yahi, P Colson, H Chahinian… - Journal of medical …, 2022 - Wiley Online Library
The recently emerging SARS‐CoV‐2 variant omicron displays an unusual association of 30
mutations, 3 deletions, and 1 insertion. To analyze the impact of this atypic mutational …

Research progress on vaccine efficacy against SARS-CoV-2 variants of concern

L Bian, J Liu, F Gao, Q Gao, Q He, Q Mao… - Human vaccines & …, 2022 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate
worldwide and a variety of variants have emerged. Variants of concern (VOC) designated by …

Impact of timing and combination of different BNT162b2 and ChAdOx1-S COVID-19 basic and booster vaccinations on humoral immunogenicity and reactogenicity in …

S Dedroogh, S Schmiedl, PA Thürmann, K Graf… - Scientific Reports, 2023 - nature.com
In this single-center observational study with 1,206 participants, we prospectively evaluated
SARS-CoV-2-antibodies (anti-S RBD) and vaccine-related adverse drug reactions (ADR) …

Omicron variant of COVID-19: A focused review of biologic, clinical, and epidemiological changes

H Majlesi, S Shahsavan, Y Farsi, A Tamimi… - Immunopathologia …, 2022 - immunopathol.com
On 25 November 2021, the world health organization listed Omicron as a newly arisen and
the fifth variant of concern (VoC) of severe acute respiratory syndrome coronavirus 2 (SARS …

SARS-CoV-2 omicron spike simulations: broad antibody escape, weakened ACE2 binding, and modest furin cleavage

MZ Jawaid, A Baidya, R Mahboubi-Ardakani… - Microbiology …, 2023 - Am Soc Microbiol
The recent emergence of the omicron variant of the SARS-CoV-2 virus with large numbers of
mutations has raised concern about a potential new surge in infections. Here we use …

[HTML][HTML] STRA6: The key to inflammatory pathways in COVID-19

AR Sarohan - Fortune Journal of Health Sciences, 2023 - fortuneonline.org
The COVID-19 pandemic, caused by SARS-CoV-2, has infected more than 260 million
people worldwide, causing more than 5.2 million deaths. Unlike other viral infections, COVID …

Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics

NJ Ose, P Campitelli, T Modi, IC Kazan, S Kumar… - Elife, 2024 - elifesciences.org
We integrate evolutionary predictions based on the neutral theory of molecular evolution
with protein dynamics to generate mechanistic insight into the molecular adaptations of the …

Lessons from a self-terminating pandemic: Vaccination, vitamin A deficiency, and a brief epidemiological overview

AR Sarohan - ScienceOpen Preprints, 2022 - scienceopen.com
Declared a pandemic by WHO in March 2020, COVID-19 infected more than 460 million
people, causing the death of more than six million people. With the Omicron variant …

Multi-receptor mechanism and retinoid signaling disorder in the pathogenesis of COVID-19

M Elkazzaz, T Haydara… - ScienceOpen …, 2022 - scienceopen.com
BackgroundMore than two years have passed since the pandemic and despite all the efforts
of researchers, the pathogenesis of COVID-19 has not yet been resolved. Multisystem …

[PDF][PDF] In silico discovery of GPCRSs and GnRHRs as Novel SARS-CoV-2 binding receptors, the Scientific Breakthrough that could explain neuroendocrine disorders …

MR Elkazzaz, A Ahmed, IM Shamkh, YEE Abo-Amer… - 2022 - academia.edu
Background Despite the intense work of researchers since the beginning of the pandemic,
the pathogenesis of COVID-19 is not yet clearly understood. It is known that SARS-CoV-2 …