Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

Equilibrium fluctuations and triggered conformational changes often underlie the functional
cycles of membrane proteins. For example, transporters mediate the passage of molecules …

ABSTRACT Introduction Solute carriers (SLCs) represent the largest group of membrane
transporters in the human genome. They play a central role in controlling the …

The Amino Acid–Polyamine-Organocation (APC) transporter GadC contributes to the
survival of pathogenic bacteria under extreme acid stress by exchanging extracellular …

L‐type amino acid transporter 1 (LAT1; SLC7A5), which preferentially transports large
neutral amino acids, is highly upregulated in various cancers. LAT1 supplies cancer cells …

Enabled by a plethora of new technologies, research in membrane transporters has
exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent …

Found in all domains of life, transporters belonging to the LeuT-fold class mediate the import
and exchange of hydrophilic and charged compounds such as amino acids, metals, and …

LAT1 and 4F2hc form a heterodimeric membrane protein complex, which functions as one of
the best characterized amino acid transporters. Since LAT1–4F2hc is required for the …

Despite having similar structures, each member of the heteromeric amino acid transporter
(HAT) family shows exquisite preference for the exchange of certain amino acids. Substrate …