Sex differences in the epilepsies and associated comorbidities: implications for use and development of pharmacotherapies

CA Christian, DS Reddy, J Maguire, PA Forcelli… - Pharmacological …, 2020 - Elsevier
The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …

Mitochondrial matters of the brain: mitochondrial dysfunction and oxidative status in epilepsy

SJ Chang, BC Yu - Journal of bioenergetics and biomembranes, 2010 - Springer
Epilepsy is a neurological disorder characterized by spontaneous, recurrent and paroxysmal
cerebral discharge, clinically leading to persistent alterations in function and morphology of …

The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats

YF Liu, F Gao, XW Li, RH Jia, XD Meng, R Zhao… - Neurochemical …, 2012 - Springer
Baicalin, a flavonoid compound purified from plant Scutellaria baicalensis Georgi, has been
reported to possess a wide variety of pharmacological properties including anti-oxidative …

Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine

RM Freitas - Neuroscience letters, 2009 - Elsevier
The relationship between free radical and scavenger enzymes has been found in the
epileptic phenomena and reactive oxygen species have been implicated in seizure-induced …

Sex-specific differences in redox homeostasis in brain norm and disease

JA Ruszkiewicz, A Miranda-Vizuete, AA Tinkov… - Journal of Molecular …, 2019 - Springer
Sex differences in brain physiology and by inference various pathologies are generally
recognized, however frequently ignored in epidemiological and experimental studies …

Redox processes in neurodegenerative disease involving reactive oxygen species

P Kovacic, R Somanathan - Current neuropharmacology, 2012 - ingentaconnect.com
Much attention has been devoted to neurodegenerative diseases involving redox
processes. This review comprises an update involving redox processes reported in the …

Gastrodin suppresses pentylenetetrazole-induced seizures progression by modulating oxidative stress in zebrafish

M Jin, Q He, S Zhang, Y Cui, L Han, K Liu - Neurochemical research, 2018 - Springer
Pentylenetetrazole (PTZ)-induced seizures in Zebrafish models are now widely accepted for
investigating human disease epilepsy. In epilepsy, the generation of oxidative stress …

Relevance of the glutathione system in temporal lobe epilepsy: evidence in human and experimental models

N Cárdenas-Rodríguez… - Oxidative medicine …, 2014 - Wiley Online Library
Oxidative stress, which is a state of imbalance in the production of reactive oxygen species
and nitrogen, is induced by a wide variety of factors. This biochemical state is associated …

[HTML][HTML] Thyroid hormones: possible roles in epilepsy pathology

SMS Tamijani, B Karimi, E Amini, M Golpich, L Dargahi… - Seizure, 2015 - Elsevier
Thyroid hormones (THs) l-thyroxine and l-triiodothyronine, primarily known as metabolism
regulators, are tyrosine-derived hormones produced by the thyroid gland. They play an …

Astaxanthin rescues neuron loss and attenuates oxidative stress induced by amygdala kindling in adult rat hippocampus

Y Lu, T Xie, XX He, ZF Mao, LJ Jia, WP Wang… - Neuroscience …, 2015 - Elsevier
Oxidative stress plays an important role in the neuronal damage induced by epilepsy. The
present study assessed the possible neuroprotective effects of astaxanthin (ATX) on …