Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration

S Fakhri, A Iranpanah, MM Gravandi, SZ Moradi… - Phytomedicine, 2021 - Elsevier
Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …

Neuroprotective phytochemicals in experimental ischemic stroke: mechanisms and potential clinical applications

H Xu, E Wang, F Chen, J Xiao… - Oxidative Medicine and …, 2021 - Wiley Online Library
Ischemic stroke is a challenging disease with high mortality and disability rates, causing a
great economic and social burden worldwide. During ischemic stroke, ionic imbalance and …

Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis

M Zheng, H Ye, X Yang, L Shen, X Dang, X Liu… - Brain, Behavior, and …, 2024 - Elsevier
Obesity is a risk factor for cognitive dysfunction and neurodegenerative disease, including
Alzheimer's disease (AD). The gut microbiota-brain axis is altered in obesity and linked to …

[HTML][HTML] Low and high doses of oral maslinic acid protect against Parkinson's disease via distinct gut microbiota-related mechanisms

X Cao, ZR Du, X Liu, X Wang, C Li, SN Zhou… - Biomedicine & …, 2023 - Elsevier
The use of oral agents that can modify the gut microbiota (GM) could be a novel preventative
or therapeutic option for Parkinson's disease (PD). Maslinic acid (MA), a pentacyclic …

Maslinic acid: a new compound for the treatment of multiple organ diseases

Y He, Y Wang, K Yang, J Jiao, H Zhan, Y Yang, D Lv… - Molecules, 2022 - mdpi.com
Maslinic acid (MA) is a pentacyclic triterpene acid, which exists in many plants, including
olive, and is highly safe for human beings. In recent years, it has been reported that MA has …

Asiatic acid and maslinic acid attenuated kainic acid-induced seizure through decreasing hippocampal inflammatory and oxidative stress

Z Wang, M Mong, Y Yang, M Yin - Epilepsy research, 2018 - Elsevier
Seizure is a neurological disorder including hippocampal oxidative and inflammatory stress,
and glutamate toxicity. Thus, any agent (s) that mitigate (s) these events in hippocampus …

Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson's Disease

CW Tsai, RT Tsai, SP Liu, CS Chen… - Cell …, 2017 - journals.sagepub.com
Parkinson's disease (PD) is the second most common degenerative disorder of the central
nervous system in the elderly. It is characterized by progressive loss of dopaminergic …

Mind–body exercises for PTSD symptoms, Depression, and anxiety in patients with PTSD: a systematic review and Meta-analysis

L Zhu, L Li, X Li, L Wang - Frontiers in Psychology, 2022 - frontiersin.org
Objectives This study aims to systematically analyze the effects of mind–body exercises on
post-traumatic stress disorder (PTSD) symptoms, depression, and anxiety in patients with …

M2 macrophages enhance the cementoblastic differentiation of periodontal ligament stem cells via the Akt and JNK pathways

X Li, XT He, DQ Kong, XY Xu, RX Wu, LJ Sun… - Stem Cells, 2019 - academic.oup.com
Although macrophage (Mφ) polarization has been demonstrated to play crucial roles in
cellular osteogenesis across the cascade of events in periodontal regeneration, how …

The effect of maslinic acid on cognitive dysfunction induced by cholinergic blockade in mice

HJ Bae, J Kim, J Kim, N Goo, M Cai… - British Journal of …, 2020 - Wiley Online Library
Background and Purpose Alzheimer's disease (AD) is the most prevalent disease
associated with cognitive dysfunction. Current AD therapeutic agents have several …