The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …

The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

The second edition of this widely cited textbook continues to provide a concise but
comprehensive introduction to cave and subterranean biology, describing this fascinating …

Periodic food shortages are a major challenge faced by organisms in natural habitats. Cave-
dwelling animals must withstand long periods of nutrient deprivation, as—in the absence of …

Mammalian studies have shaped our understanding of the endocrine control of appetite and
body weight in vertebrates and provided the basic vertebrate model that involves central …

Understanding the molecular basis of repeatedly evolved phenotypes can yield key insights
into the evolutionary process. Quantifying gene flow between populations is especially …

The small teleost fish Astyanax mexicanus has emerged as an outstanding model for
studying many biological topics in the context of evolution. A major attribute is conspecific …

Identifying the genetic factors that underlie complex traits is central to understanding the
mechanistic underpinnings of evolution. Cave-dwelling Astyanax mexicanus populations …