Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

BACKGROUND Although laboratory procedures, along with culture media formulations,
have improved over the past two decades, the issue remains that human IVF is performed in …

Human reproduction is characterized by a high degree of embryo wastage, which is largely
ascribed to a high prevalence of embryo aneuploidy. It is proposed that maternal strategies …

This review considers how our understanding of preimplantation embryo metabolism has
progressed since the pioneering work on this topic in the late 1960s and early 1970s …

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in
embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight …

Mobilization of fatty acids from adipose tissue during metabolic stress will increase the
amount of free fatty acids in blood and follicular fluid and, thus, may affect oocyte quality. In …

The field of plasma medicine has seen substantial advances over the last decade, with
applications developed for bacterial sterilisation, wound healing and cancer treatment. Low …

Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal
disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment …

Background: In recent years, the rapidly advancing field of low-temperature atmospheric
pressure plasmas has shown considerable promise for future translational biomedical …

This review examines the 'Quiet Embryo Hypothesis' which proposes that viable
preimplantation embryos operate at metabolite or nutrient turnover rates distributed within …