Abstract 'Jack of all trades, master of everything'is a fair label for transforming growth factor
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …

Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and
biomedical interest. Recently, trophic activities of MSCs have become the topic of a number …

The TGF-β1 cytokine is a key mediator of many biological processes. Complex regulatory
mechanisms are in place that allow one single molecule to exert so many distinct …

Multipotent mesenchymal stromal cells (MSCs) represent a promising cell-based therapy in
regenerative medicine and for the treatment of inflammatory/autoimmune diseases …

Mesenchymal stem cells (MSCs) are multipotent stem cells, whose paracrine and
immunomodulatory potential has made them a promising candidate for central nervous …

GARP (glycoprotein-A repetitions predominant) is a type I transmembrane cell surface
docking receptor for latent transforming growth factor-β (TGF-β) that is abundantly expressed …

Human regulatory T cells (Tregs) suppress other T cells by converting the latent, inactive
form of TGF-β1 into active TGF-β1. In Tregs, TGF-β1 activation requires GARP, a …

Damaged cartilage has poor self-healing ability and usually progresses to scar or
fibrocartilaginous tissue, and finally degenerates to osteoarthritis (OA). Here we …

Ischemic stroke is one of the major causes of death and disability in the world. Currently,
most patients cannot choose intravenous thrombolysis or intravascular mechanical …

Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when
combined, make them ideally suited for cellular-based immunotherapy and as vehicles for …