Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-
stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but …

Human stem-cell-derived models provide the promise of accelerating our understanding of
brain disorders, but not knowing whether they possess the ability to mature beyond mid-to …

The COVID-19 outbreak has become a global health risk, and understanding the response
of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host …

Most patients with cancer either do not respond to immune checkpoint blockade or develop
resistance to it, often because of acquired mutations that impair antigen presentation. Here …

RNA editing by adenosine deaminases changes the information encoded in the mRNA from
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …

Circular RNA s (circ RNA s) are brain‐abundant RNA s of mostly unknown functions. To
seek their roles in Parkinson's disease (PD), we generated an RNA sequencing resource of …

Circular RNAs (circRNAs) are a large class of animal RNAs. To investigate possible circRNA
functions, it is important to understand circRNA biogenesis. Besides human ALU repeats …

Adenosine-to-inosine (A-to-I) editing is a highly prevalent posttranscriptional modification of
RNA, mediated by ADAR (adenosine deaminase acting on RNA) enzymes. In addition to …

Naïve and primed pluripotent states retain distinct molecular properties, yet limited
knowledge exists on how their state transitions are regulated. Here, we identify Mettl3, an N …