[HTML][HTML] Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Multivariable prediction models for fetal macrosomia and large for gestational age: A systematic review

L Ewington, N Black, C Leeson… - … Journal of Obstetrics …, 2024 - Wiley Online Library
Background The identification of large for gestational age (LGA) and macrosomic fetuses is
essential for counselling and managing these pregnancies. Objectives To systematically …

Maternal body mass index, early-pregnancy metabolite profile, and birthweight

RJ Wahab, VWV Jaddoe, E Voerman… - The Journal of …, 2022 - academic.oup.com
Context Maternal prepregnancy body mass index (BMI) has a strong influence on
gestational metabolism, but detailed metabolic alterations are unknown. Objective First, to …

[HTML][HTML] Putrescine as a novel biomarker of maternal serum in first trimester for the prediction of gestational diabetes mellitus: A nested case-control study

C Liu, Y Wang, W Zheng, J Wang, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Aims Early identification of gestational diabetes mellitus (GDM) aims to reduce the risk of
adverse maternal and perinatal outcomes. Currently, no acknowledged biomarker has …

[HTML][HTML] Do mass spectrometry-derived metabolomics improve the prediction of pregnancy-related disorders? Findings from a UK birth cohort with independent …

N McBride, P Yousefi, U Sovio, K Taylor, Y Vafai… - Metabolites, 2021 - mdpi.com
Many women who experience gestational diabetes (GDM), gestational hypertension (GHT),
pre-eclampsia (PE), have a spontaneous preterm birth (sPTB) or have an offspring born …

The role of lipid dysregulation in gestational diabetes mellitus: Early prediction and postpartum prognosis

Z Zhang, Z Zhou, H Li - Journal of Diabetes Investigation, 2024 - Wiley Online Library
Gestational diabetes mellitus (GDM) is a pathological condition during pregnancy
characterized by impaired glucose tolerance, and the failure of pancreatic beta‐cells to …

[HTML][HTML] Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence

C Hübel, M Herle, DL Santos Ferreira, M Abdulkadir… - Scientific reports, 2021 - nature.com
Childhood eating behaviour contributes to the rise of obesity and related noncommunicable
disease worldwide. However, we lack a deep understanding of biochemical alterations that …

[HTML][HTML] Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective …

J Villar, R Ochieng, RB Gunier… - The Lancet Diabetes & …, 2022 - thelancet.com
Background Obesity predominantly affects populations in high-income countries and those
countries facing epidemiological transition. The risk of childhood obesity is increased among …

Metabolic profiling of pregnancies complicated by preeclampsia: A longitudinal study

HN Skytte, JJ Christensen, N Gunnes… - Acta obstetricia et …, 2023 - Wiley Online Library
Introduction Preeclampsia is associated with maternal metabolic disturbances, but
longitudinal studies with comprehensive metabolic profiling are lacking. We aimed to …

[HTML][HTML] Using Mendelian randomisation to prioritise candidate maternal metabolic traits influencing offspring birthweight

CJS Barry, DA Lawlor, CY Shapland, E Sanderson… - Metabolites, 2022 - mdpi.com
Marked physiological changes in pregnancy are essential to support foetal growth; however,
evidence on the role of specific maternal metabolic traits from human studies is limited. We …