Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …

It has been more than 15 years since the identification of individual interleukin-27 (IL-27)
and IL-27 receptor components. The last decade has seen the description of the signaling …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Review highlights the function of the cytokine receptor gp130, specifically the diverse roles it
plays in inflammation, autoimmunity, and cancer. Glycoprotein 130 (gp130) is a shared …

Asthma is a common, disabling inflammatory respiratory disease that has increased in
frequency and severity in developed nations. We review studies of murine allergic airway …

The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its
receptor, combined with gp130, a common receptor chain used by several cytokines …

Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines,
alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced …

Initial studies on the biology of IL-27 provided evidence of a role for this cytokine in the
initiation of Th1 responses; however, subsequent work using models of pathogen-induced …

Interferon (IFN)-β is a commonly used therapy for relapsing remitting multiple sclerosis
(RRMS). However its protective mechanism is still unclear and the failure of many patients to …

Background The pathogenesis of severe asthma in childhood remains poorly understood.
Objective We sought to construct the immunologic landscape in the airways of children with …