Recent development of innovative tools for live imaging of actin filaments (F-actin) enabled
the detection of surprising nuclear structures responding to various stimuli, challenging …

Liquid-liquid phase separation (LLPS) has emerged as a central player in the assembly of
membraneless compartments termed biomolecular condensates. These compartments are …

Cellular processes are influenced by liquid phase separation, but its role in DNA repair is
unclear. Here, we show that in Saccharomyces cerevisiae, liquid droplets made up of DNA …

Cells rapidly respond to replication stress actively slowing fork progression and inducing
fork reversal. How replication fork plasticity is achieved in the context of nuclear organization …

The nucleus is a dynamic environment containing chromatin, membraneless organelles,
and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA …

The ribosomal DNA (rDNA) represents a particularly unstable locus undergoing frequent
breakage. DNA double-strand breaks (DSBs) within rDNA induce both rDNA transcriptional …

Searching for factors to improve knockin efficiency for therapeutic applications,
biotechnology, and generation of non-human primate models of disease, we found that the …

The intracellular environment is partitioned into functionally distinct compartments
containing specific sets of molecules and reactions. Biomolecular condensates, also …

In eukaryotes, detection and repair of DNA double-strand breaks (DSBs) operate within
chromatin, an incredibly complex structure that tightly packages and regulates DNA …

DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates
with age, in which cytoskeletal proteins are polymerized to repair DSB in dividing cells …