Current anti-diabetic agents and their molecular targets: A review

N Kerru, A Singh-Pillay, P Awolade, P Singh - European Journal of …, 2018 - Elsevier
Diabetes mellitus is a medical condition characterized by the body's loss of control over
blood sugar. The frequency of diagnosed cases and consequential increases in medical …

Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack

U Ghani - European journal of medicinal chemistry, 2015 - Elsevier
Abstract Treatment of diabetes mellitus by oral α-glucosidase inhibitors is currently confined
to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects …

Human intestinal maltase–glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity

L Sim, R Quezada-Calvillo, EE Sterchi… - Journal of Molecular …, 2008 - Elsevier
Human maltase–glucoamylase (MGAM) is one of the two enzymes responsible for
catalyzing the last glucose-releasing step in starch digestion. MGAM is anchored to the …

Structural insight into substrate specificity of human intestinal maltase-glucoamylase

L Ren, X Qin, X Cao, L Wang, F Bai, G Bai, Y Shen - Protein & cell, 2011 - Springer
Human maltase-glucoamylase (MGAM) hydrolyzes linear alpha-1, 4-linked oligosaccharide
substrates, playing a crucial role in the production of glucose in the human lumen and acting …

Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains

L Sim, C Willemsma, S Mohan, HY Naim… - Journal of Biological …, 2010 - ASBMB
Human maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) are small intestinal
enzymes that work concurrently to hydrolyze the mixture of linear α-1, 4-and branched α-1, 6 …

The medicinal chemistry of dengue virus

MAM Behnam, C Nitsche, V Boldescu… - Journal of medicinal …, 2016 - ACS Publications
The dengue virus and related flaviviruses are an increasing global health threat. In this
perspective, we comment on and review medicinal chemistry efforts aimed at the prevention …

Enzymatic conversions of starch

P Tomasik, D Horton - Advances in carbohydrate chemistry and …, 2012 - Elsevier
This article surveys methods for the enzymatic conversion of starch, involving hydrolases
and nonhydrolyzing enzymes, as well as the role of microorganisms producing such …

Contribution of the individual small intestinal α-glucosidases to digestion of unusual α-linked glycemic disaccharides

BH Lee, DR Rose, AHM Lin… - Journal of Agricultural …, 2016 - ACS Publications
The mammalian mucosal α-glucosidase complexes, maltase–glucoamylase (MGAM) and
sucrase–isomaltase (SI), have two catalytic subunits (N-and C-termini). Concurrent with the …

How the walls come crumbling down: recent structural biochemistry of plant polysaccharide degradation

HJ Gilbert, H Stålbrand, H Brumer - Current opinion in plant biology, 2008 - Elsevier
The recent years have witnessed considerable developments in the interpretation of the
three-dimensional structures of plant polysaccharide-degrading enzymes in the context of …

A subfamily classification to choreograph the diverse activities within glycoside hydrolase family 31

T Arumapperuma, J Li, B Hornung, NM Soler… - Journal of Biological …, 2023 - ASBMB
The Carbohydrate-Active Enzyme classification groups enzymes that breakdown, assemble,
or decorate glycans into protein families based on sequence similarity. The glycoside …