Regulatory T cells and human disease
S Sakaguchi, N Mikami, JB Wing… - Annual review of …, 2020 - annualreviews.org
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
Targeting Treg cells in cancer immunotherapy
A Tanaka, S Sakaguchi - European journal of immunology, 2019 - Wiley Online Library
Foxp3‐expressing regulatory T (Treg) cells, which are indispensable for preventing
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …
Human FOXP3+ regulatory T cell heterogeneity and function in autoimmunity and cancer
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
Regulatory T cells in cancer immunotherapy
A Tanaka, S Sakaguchi - Cell research, 2017 - nature.com
FOXP3-expressing regulatory T (Treg) cells, which suppress aberrant immune response
against self-antigens, also suppress anti-tumor immune response. Infiltration of a large …
against self-antigens, also suppress anti-tumor immune response. Infiltration of a large …
An essential role for the IL-2 receptor in Treg cell function
Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor
(IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for …
(IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for …
Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers
T Saito, H Nishikawa, H Wada, Y Nagano… - Nature medicine, 2016 - nature.com
CD4+ T cells that express the forkhead box P3 (FOXP3) transcription factor function as
regulatory T (Treg) cells and hinder effective immune responses against cancer cells …
regulatory T (Treg) cells and hinder effective immune responses against cancer cells …
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
Foxp3-expressing CD4+ CD25+ regulatory T cells (Tregs) constitutively and highly express
the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) …
the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) …
[HTML][HTML] Confusing signals: recent progress in CTLA-4 biology
LSK Walker, DM Sansom - Trends in immunology, 2015 - cell.com
The mechanism of action of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) remains
surprisingly unclear. Regulatory T (Treg) cells can use CTLA-4 to elicit suppression; …
surprisingly unclear. Regulatory T (Treg) cells can use CTLA-4 to elicit suppression; …
Molecular and cellular functions of CTLA-4
S Van Coillie, B Wiernicki, J Xu - Regulation of Cancer Immune …, 2020 - Springer
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to
the CD28 immunoglobulin subfamily, expressed primarily by T-cells. Its ligands, CD80 and …
the CD28 immunoglobulin subfamily, expressed primarily by T-cells. Its ligands, CD80 and …
Treg cells in autoimmunity: from identification to Treg-based therapies
L Göschl, C Scheinecker, M Bonelli - Seminars in immunopathology, 2019 - Springer
Regulatory (Treg) cells are key regulators of inflammation and important for immune
tolerance and homeostasis. A major progress has been made in the identification and …
tolerance and homeostasis. A major progress has been made in the identification and …