Understanding host responses to equine encephalitis virus infection: implications for therapeutic development
K Kehn-Hall, SB Bradfute - Expert Review of Anti-infective Therapy, 2022 - Taylor & Francis
Introduction Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV,
and WEEV) are mosquito-borne New World alphaviruses that cause encephalitis in equids …
and WEEV) are mosquito-borne New World alphaviruses that cause encephalitis in equids …
New World alphavirus protein interactomes from a therapeutic perspective
BD Carey, A Bakovic, V Callahan, A Narayanan… - Antiviral research, 2019 - Elsevier
Abstract The New World alphaviruses, Venezuelan, eastern and western equine
encephalitis viruses (VEEV, EEEV, and WEEV), are important human pathogens due to their …
encephalitis viruses (VEEV, EEEV, and WEEV), are important human pathogens due to their …
Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses
Abstract The New World alphaviruses–Venezuelan, eastern, and western equine
encephalitis viruses (VEEV, EEEV, and WEEV respectively)–cause a febrile disease that is …
encephalitis viruses (VEEV, EEEV, and WEEV respectively)–cause a febrile disease that is …
The sticky business of Alphavirus capsid–host interactions
Alphaviruses are a serious threat to global health and can cause lethal encephalitic or
arthritogenic disease in humans and animals. As there are no licensed antivirals, it is critical …
arthritogenic disease in humans and animals. As there are no licensed antivirals, it is critical …
Advances in the development of small molecule antivirals against equine encephalitic viruses
TJ Ogorek, JE Golden - Viruses, 2023 - mdpi.com
Venezuelan, western, and eastern equine encephalitic alphaviruses (VEEV, WEEV, and
EEEV, respectively) are arboviruses that are highly pathogenic to equines and cause …
EEEV, respectively) are arboviruses that are highly pathogenic to equines and cause …
To be or not to be phosphorylated: Understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host …
L Kämper, I Kuhl, M Vallbracht, T Hoenen… - Emerging Microbes & …, 2024 - Taylor & Francis
Ebola virus (EBOV) transcription is essentially regulated via dynamic dephosphorylation of
its viral transcription activator VP30 by the host phosphatase PP2A. The nucleoprotein NP …
its viral transcription activator VP30 by the host phosphatase PP2A. The nucleoprotein NP …
Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3
A Bakovic, N Bhalla, F Alem, C Campbell, W Zhou… - Viruses, 2021 - mdpi.com
Venezuelan equine encephalitis virus (VEEV) is a new world alphavirus and a category B
select agent. Currently, no FDA-approved vaccines or therapeutics are available to treat …
select agent. Currently, no FDA-approved vaccines or therapeutics are available to treat …
CK1 and PP1 regulate Rift Valley fever virus genome replication through L protein phosphorylation
N Bracci, A Baer, R Flor, K Petraccione, T Stocker… - Antiviral Research, 2024 - Elsevier
Rift Valley fever virus (RVFV) is an arbovirus in the Phenuiviridae family identified initially by
the large 'abortion storms' observed among ruminants; RVFV can also infect humans. In …
the large 'abortion storms' observed among ruminants; RVFV can also infect humans. In …
Targeting the non-catalytic RVxF site of protein phosphatase-1 with small molecules for Ebola virus inhibition
Ebola virus (EBOV) is a non-segmented negative-sense RNA virus that causes a severe
human disease. The ongoing EBOV outbreak in the Eastern part of Democratic Republic of …
human disease. The ongoing EBOV outbreak in the Eastern part of Democratic Republic of …
Capsid protein mediated evasion of IRAK1-dependent signalling is essential to Sindbis virus neuroinvasion and virulence in mice
Alphaviruses are arthropod-borne, single-stranded positive-sense RNA viruses that are
recognized as rapidly emerging pathogens. Despite being exquisitely sensitive to the effects …
recognized as rapidly emerging pathogens. Despite being exquisitely sensitive to the effects …