Cerebral edema formation after stroke: emphasis on blood–brain barrier and the lymphatic drainage system of the brain
S Chen, L Shao, L Ma - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Brain edema is a severe stroke complication that is associated with prolonged
hospitalization and poor outcomes. Swollen tissues in the brain compromise cerebral …
hospitalization and poor outcomes. Swollen tissues in the brain compromise cerebral …
[HTML][HTML] The SLC9A-C mammalian Na+/H+ exchanger family: molecules, mechanisms, and physiology
SF Pedersen, L Counillon - Physiological reviews, 2019 - journals.physiology.org
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …
A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion
HW Morrison, JA Filosa - Journal of neuroinflammation, 2013 - Springer
Background Microglia cells continuously survey the healthy brain in a ramified morphology
and, in response to injury, undergo progressive morphological and functional changes that …
and, in response to injury, undergo progressive morphological and functional changes that …
Ion channels and transporters in microglial function in physiology and brain diseases
Microglial cells interact with all components of the central nervous system (CNS) and are
increasingly recognized to play essential roles during brain development, homeostasis and …
increasingly recognized to play essential roles during brain development, homeostasis and …
Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse …
S Wang, H Jing, H Yang, Z Liu, H Guo, L Chai… - Journal of …, 2015 - Elsevier
Abstract Ethnopharmacological relevance Radix Salviae Miltiorrhizae, known as Danshen,
is a well-known traditional Chinese herb which has been used extensively for the treatment …
is a well-known traditional Chinese herb which has been used extensively for the treatment …
Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy
E Boedtkjer, L Bunch… - Current pharmaceutical …, 2012 - ingentaconnect.com
The Na+/H+-exchanger 1, NHE1 (SLC9A1) and the electroneutral Na+, HCO3--
cotransporter NBCn1 (SLC4A7) are coexpressed in a wide range of tissues. Under normal …
cotransporter NBCn1 (SLC4A7) are coexpressed in a wide range of tissues. Under normal …
Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke
Stimulation of Na+/H+ exchanger isoform 1 (NHE1) in astrocytes causes ionic dysregulation
under ischemic conditions. In this study, we created a Nhe1flox/flox (Nhe1f/f) mouse line with …
under ischemic conditions. In this study, we created a Nhe1flox/flox (Nhe1f/f) mouse line with …
Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?
Ischemic brain injury results from complicated cellular mechanisms. The present therapy for
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …
Administration of DHA reduces endoplasmic reticulum stress-associated inflammation and alters microglial or macrophage activation in traumatic brain injury
We investigated the effects of the administration of docosahexaenoic acid (DHA) post-
traumatic brain injury (TBI) on reducing neuroinflammation. TBI was induced by cortical …
traumatic brain injury (TBI) on reducing neuroinflammation. TBI was induced by cortical …
NHE-1: still a viable therapeutic target
M Karmazyn - Journal of molecular and cellular cardiology, 2013 - Elsevier
The concept of Nasingle bond H exchange (NHE) involvement in cardiac pathology has
been espoused for decades and supported by a plethora of experimental studies …
been espoused for decades and supported by a plethora of experimental studies …