Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

ABSTRACT Introduction Polo Like Kinase 1 (PLK1) is a key regulator of mitosis and its
overexpression is frequently observed in a wide variety of human cancers, while often being …

In previous studies, we synthesized different imidazo− pyrazoles 1 and 2 with interesting
anticancer, anti‐angiogenic and anti‐inflammatory activities. To further extend the structure …

Available vaccine-based immunity may at high risk of being evaded due to substantial
mutations in the variant Omicron. The main protease (Mpro) of SARS-CoV-2 and human …

There are many multidomain allosteric proteins where an allosteric signal at the allosteric
domain modifies the activity of the functional domain. Intrinsically disordered regions …

Natural products (NPs) are a rich source of drug discovery, and some of them act by
covalently binding to the targets. Recently, targeted covalent natural product (TCNP) design …

Tubulin inhibitors have been considered as potential drugs for cancer therapy. However,
their drug resistance and serious side-effects are the main reasons for clinical treatment …

Thiourea derivatives have drawn much attention for their latent capacities of biological
activities. In this study, we designed acylthiourea compounds as polo-like kinase 1 (Plk1) …

The Polo-like kinases (Plks) are an evolutionary conserved family of Ser/Thr protein kinases
that possess, in addition to the classical kinase domain at the N-terminus, a C-terminal polo …

Aurora and polo-like kinases control the G2/M phase in cell mitosis, which are both
considered as crucial targets for cancer cell proliferations. Here, naphthalene-based …