A guide to membraneless organelles and their various roles in gene regulation

T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

[HTML][HTML] G3BP1 is a tunable switch that triggers phase separation to assemble stress granules

P Yang, C Mathieu, RM Kolaitis, P Zhang, J Messing… - Cell, 2020 - cell.com
The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …

Stress granules and neurodegeneration

B Wolozin, P Ivanov - Nature Reviews Neuroscience, 2019 - nature.com
Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …

Mammalian stress granules and P bodies at a glance

CL Riggs, N Kedersha, P Ivanov… - Journal of cell …, 2020 - journals.biologists.com
Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-
based cellular compartments that assemble in response to stress. SGs and PBs form …

[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly

S Hofmann, N Kedersha, P Anderson… - Biochimica et Biophysica …, 2021 - Elsevier
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …

The molecular language of membraneless organelles

E Gomes, J Shorter - Journal of Biological Chemistry, 2019 - ASBMB
Eukaryotic cells organize their intracellular components into organelles that can be
membrane-bound or membraneless. A large number of membraneless organelles, including …

Liquid phase condensation in cell physiology and disease

Y Shin, CP Brangwynne - Science, 2017 - science.org
BACKGROUND Living cells contain distinct subcompartments to facilitate spatiotemporal
regulation of biological reactions. In addition to canonical membrane-bound organelles such …

Biomolecular condensates: organizers of cellular biochemistry

SF Banani, HO Lee, AA Hyman… - Nature reviews Molecular …, 2017 - nature.com
Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack
surrounding membranes but function to concentrate proteins and nucleic acids. These …

α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis

S Mehra, S Sahay, SK Maji - Biochimica et Biophysica Acta (BBA)-Proteins …, 2019 - Elsevier
Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …